Synapses form in skeletal muscles lacking neuregulin receptors.

Détails

ID Serval
serval:BIB_EE8AE266DF25
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Synapses form in skeletal muscles lacking neuregulin receptors.
Périodique
Science (new York, N.y.)
Auteur⸱e⸱s
Escher P., Lacazette E., Courtet M., Blindenbacher A., Landmann L., Bezakova G., Lloyd K.C., Mueller U., Brenner H.R.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
06/2005
Peer-reviewed
Oui
Volume
308
Numéro
5730
Pages
1920-1923
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
The formation of the neuromuscular junction (NMJ) is directed by reciprocal interactions between motor neurons and muscle fibers. Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated. Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin. We therefore conclude that NRG signaling to muscle is not required for NMJ formation. The effects of NRG signaling to muscle may be mediated indirectly through Schwann cells.
Mots-clé
Agrin/physiology, Animals, Animals, Newborn, Cells, Cultured, Genes, erbB, Genes, erbB-2, Membrane Potentials, Mice, Motor Endplate/metabolism, Motor Endplate/physiology, Muscle, Skeletal/innervation, Muscle, Skeletal/ultrastructure, Mutation, Neuregulins/metabolism, Neuromuscular Junction/embryology, Neuromuscular Junction/metabolism, Presynaptic Terminals/physiology, RNA, Messenger/genetics, RNA, Messenger/metabolism, Receptor, Epidermal Growth Factor/genetics, Receptor, Epidermal Growth Factor/physiology, Receptor, ErbB-2/genetics, Receptor, ErbB-2/physiology, Receptor, ErbB-4, Receptors, Cholinergic/chemistry, Receptors, Cholinergic/genetics, Recombination, Genetic, Schwann Cells/physiology, Signal Transduction, Synaptic Transmission
Pubmed
Création de la notice
28/02/2015 22:19
Dernière modification de la notice
20/08/2019 16:16
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