Synapses form in skeletal muscles lacking neuregulin receptors.
Details
Serval ID
serval:BIB_EE8AE266DF25
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Synapses form in skeletal muscles lacking neuregulin receptors.
Journal
Science (new York, N.y.)
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Publication state
Published
Issued date
06/2005
Peer-reviewed
Oui
Volume
308
Number
5730
Pages
1920-1923
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Abstract
The formation of the neuromuscular junction (NMJ) is directed by reciprocal interactions between motor neurons and muscle fibers. Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated. Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin. We therefore conclude that NRG signaling to muscle is not required for NMJ formation. The effects of NRG signaling to muscle may be mediated indirectly through Schwann cells.
Keywords
Agrin/physiology, Animals, Animals, Newborn, Cells, Cultured, Genes, erbB, Genes, erbB-2, Membrane Potentials, Mice, Motor Endplate/metabolism, Motor Endplate/physiology, Muscle, Skeletal/innervation, Muscle, Skeletal/ultrastructure, Mutation, Neuregulins/metabolism, Neuromuscular Junction/embryology, Neuromuscular Junction/metabolism, Presynaptic Terminals/physiology, RNA, Messenger/genetics, RNA, Messenger/metabolism, Receptor, Epidermal Growth Factor/genetics, Receptor, Epidermal Growth Factor/physiology, Receptor, ErbB-2/genetics, Receptor, ErbB-2/physiology, Receptor, ErbB-4, Receptors, Cholinergic/chemistry, Receptors, Cholinergic/genetics, Recombination, Genetic, Schwann Cells/physiology, Signal Transduction, Synaptic Transmission
Pubmed
Create date
28/02/2015 23:19
Last modification date
20/08/2019 17:16
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