Differentiation towards regulatory DC is maintained during RSV infection in airway epithelial cells

Détails

ID Serval
serval:BIB_EE81A76010DC
Type
Non publié: un document ayant un auteur et un titre, mais non publié.
Collection
Publications
Institution
Titre
Differentiation towards regulatory DC is maintained during RSV infection in airway epithelial cells
Auteur⸱e⸱s
Obregon Carolina, Van der Sluijs Koenraad F., Geiser Thomas K. Mühlemann Kathrin , Nicod Laurent P.
Date de publication
2010
Langue
anglais
Notes
Non publié
Résumé
Airway epithelial cells have been shown to drive differentiation of monocytes into dendritic cells (DC) with suppressive phenotype. In this study we investigated the impact of virus-induced inflammatory mediator production on DC development. Monocyte differentiation into functional DC, as reflected by the expression of CD11c, CD123, BDCA-4 and DC-SIGN and the capacity to activate T cells, was similar for respiratory syncytial virus (RSV)- and mock-infected BEAS-2B and A549 cells. RSV-conditioned culture media resulted in a partially mature DC phenotype, but failed to upregulate CD80, CD83, CD86 and CCR7 and failed to release pro-inflammatory mediators upon TLR triggering. Nevertheless, these DCs were able to maintain an antiviral response by the release of type I IFN. Collectively, these data indicate that the airway epithelium maintains an important suppressive DC phenotype under inflammatory conditions induced by RSV infection.
Création de la notice
12/02/2010 16:21
Dernière modification de la notice
20/08/2019 16:16
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