Differentiation towards regulatory DC is maintained during RSV infection in airway epithelial cells

Details

Serval ID
serval:BIB_EE81A76010DC
Type
Unpublished: a document having an author and title, but not formally published.
Collection
Publications
Institution
Title
Differentiation towards regulatory DC is maintained during RSV infection in airway epithelial cells
Author(s)
Obregon Carolina, Van der Sluijs Koenraad F., Geiser Thomas K. Mühlemann Kathrin , Nicod Laurent P.
Issued date
2010
Language
english
Notes
Non publié
Abstract
Airway epithelial cells have been shown to drive differentiation of monocytes into dendritic cells (DC) with suppressive phenotype. In this study we investigated the impact of virus-induced inflammatory mediator production on DC development. Monocyte differentiation into functional DC, as reflected by the expression of CD11c, CD123, BDCA-4 and DC-SIGN and the capacity to activate T cells, was similar for respiratory syncytial virus (RSV)- and mock-infected BEAS-2B and A549 cells. RSV-conditioned culture media resulted in a partially mature DC phenotype, but failed to upregulate CD80, CD83, CD86 and CCR7 and failed to release pro-inflammatory mediators upon TLR triggering. Nevertheless, these DCs were able to maintain an antiviral response by the release of type I IFN. Collectively, these data indicate that the airway epithelium maintains an important suppressive DC phenotype under inflammatory conditions induced by RSV infection.
Create date
12/02/2010 17:21
Last modification date
20/08/2019 17:16
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