Nitric oxide modulates endogenous dopamine release in bovine retina
Détails
ID Serval
serval:BIB_EC4F5AD2C6F0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Nitric oxide modulates endogenous dopamine release in bovine retina
Périodique
Neuroreport
ISSN
0959-4965 (Print)
Statut éditorial
Publié
Date de publication
01/1994
Volume
5
Numéro
4
Pages
401-4
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 12
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 12
Résumé
A study of the possible modulation by nitric oxide (NO) of endogenous dopamine (DA) release was performed in bovine retina in vitro. NO synthase activity was measured in retinal homogenates and totally blocked by L-nitroarginine methyl ester (L-NA). Intact retinas were also exposed to hydroxylamine, an NO-generator which significantly decreased both basal and potassium-induced liberation of DA. In contrast, dibutyryl cGMP was ineffective. Furthermore, L-NA was able to increase basal DA release, its effects being potentiated in calcium free medium. Taken together, these results suggest that endogenous NO regulates DA release via cGMP independent mechanisms.
Mots-clé
Amino Acid Oxidoreductases/antagonists & inhibitors
Animals
Arginine/analogs & derivatives/pharmacology
Basal Metabolism
Calcium/physiology
Cattle
Culture Media
Cyclic GMP/biosynthesis
Dibutyryl Cyclic GMP/pharmacology
Dopamine/*metabolism
Feedback
Hydroxylamine
Hydroxylamines/pharmacology
NG-Nitroarginine Methyl Ester
Nitric Oxide/antagonists & inhibitors/*physiology
Nitric Oxide Synthase
Retina/*metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 12:42
Dernière modification de la notice
20/08/2019 17:14