Nitric oxide modulates endogenous dopamine release in bovine retina

Details

Serval ID
serval:BIB_EC4F5AD2C6F0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nitric oxide modulates endogenous dopamine release in bovine retina
Journal
Neuroreport
Author(s)
Bugnon  O., Schaad  N. C., Schorderet  M.
ISSN
0959-4965 (Print)
Publication state
Published
Issued date
01/1994
Volume
5
Number
4
Pages
401-4
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 12
Abstract
A study of the possible modulation by nitric oxide (NO) of endogenous dopamine (DA) release was performed in bovine retina in vitro. NO synthase activity was measured in retinal homogenates and totally blocked by L-nitroarginine methyl ester (L-NA). Intact retinas were also exposed to hydroxylamine, an NO-generator which significantly decreased both basal and potassium-induced liberation of DA. In contrast, dibutyryl cGMP was ineffective. Furthermore, L-NA was able to increase basal DA release, its effects being potentiated in calcium free medium. Taken together, these results suggest that endogenous NO regulates DA release via cGMP independent mechanisms.
Keywords
Amino Acid Oxidoreductases/antagonists & inhibitors Animals Arginine/analogs & derivatives/pharmacology Basal Metabolism Calcium/physiology Cattle Culture Media Cyclic GMP/biosynthesis Dibutyryl Cyclic GMP/pharmacology Dopamine/*metabolism Feedback Hydroxylamine Hydroxylamines/pharmacology NG-Nitroarginine Methyl Ester Nitric Oxide/antagonists & inhibitors/*physiology Nitric Oxide Synthase Retina/*metabolism
Pubmed
Web of science
Create date
28/01/2008 11:42
Last modification date
20/08/2019 16:14
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