Diagnostic strategies for SARS-CoV-2 infection and interpretation of microbiological results.

Détails

ID Serval
serval:BIB_EB349E4D572A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Diagnostic strategies for SARS-CoV-2 infection and interpretation of microbiological results.
Périodique
Clinical microbiology and infection
Auteur(s)
Caruana G., Croxatto A., Coste A.T., Opota O., Lamoth F., Jaton K., Greub G.
ISSN
1469-0691 (Electronic)
ISSN-L
1198-743X
Statut éditorial
Publié
Date de publication
09/2020
Peer-reviewed
Oui
Volume
26
Numéro
9
Pages
1178-1182
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
To face the current COVID-19 pandemic, diagnostic tools are essential. It is recommended to use real-time RT-PCR for RNA viruses in order (a) to perform a rapid and accurate diagnostic, (b) to guide patient care and management and (c) to guide epidemiological strategies. Further studies are warranted to define the role of serological diagnosis and a possible correlation between serological response and prognosis.
The aim was to guide clinical microbiologists in the use of these diagnostic tests and clinicians in the interpretation of their results.
A search of literature was performed through PubMed and Google Scholar using the keywords SARS-CoV-2, SARS-CoV-2 molecular diagnosis, SARS-CoV-2 immune response, SARS-CoV-2 serology/antibody testing, coronavirus diagnosis.
The present review discusses performances, limitations and use of current and future diagnostic tests for SARS-CoV-2.
Real-time RT-PCR remains the reference method for diagnosis of SARS-CoV-2 infection. On the other hand, notwithstanding its varying sensitivity according to the time of infection, serology represents a valid asset (a) to try to solve possible discrepancies between a highly suggestive clinical and radiological presentation and negative RT-PCR, (b) to solve discrepancies between different PCR assays and (c) for epidemiological purposes.
Mots-clé
Antibodies, Viral/blood, COVID-19/diagnosis, COVID-19 Nucleic Acid Testing, COVID-19 Serological Testing, COVID-19 Testing/methods, Humans, Real-Time Polymerase Chain Reaction, COVID-19, Coronavirus, Molecular diagnostic testing, Reverse transcriptase polymerase chain reaction, SARS-COV-2, Serology
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/07/2020 16:48
Dernière modification de la notice
30/12/2020 6:24
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