The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals.

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ID Serval
serval:BIB_EAE845542422
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Production externe
Titre
The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals.
Périodique
Clinical proteomics
Auteur⸱e⸱s
Butler-Laporte G., Gonzalez-Kozlova E., Su C.Y., Zhou S., Nakanishi T., Brunet-Ratnasingham E., Morrison D., Laurent L., Afilalo J., Afilalo M., Henry D., Chen Y., Carrasco-Zanini J., Farjoun Y., Pietzner M., Kimchi N., Afrasiabi Z., Rezk N., Bouab M., Petitjean L., Guzman C., Xue X., Tselios C., Vulesevic B., Adeleye O., Abdullah T., Almamlouk N., Moussa Y., DeLuca C., Duggan N., Schurr E., Brassard N., Durand M., Del Valle D.M., Thompson R., Cedillo M.A., Schadt E., Nie K., Simons N.W., Mouskas K., Zaki N., Patel M., Xie H., Harris J., Marvin R., Cheng E., Tuballes K., Argueta K., Scott I., Greenwood CMT, Paterson C., Hinterberg M., Langenberg C., Forgetta V., Mooser V., Marron T., Beckmann N., Kenigsberg E., Charney A.W., Kim-Schulze S., Merad M., Kaufmann D.E., Gnjatic S., Richards J.B.
Collaborateur⸱rice⸱s
Mount Sinai COVID-19 Biobank Team
Contributeur⸱rice⸱s
Agashe C., Agrawal P., Akyatan A., Alesso-Carra K., Alibo E., Alvarez K., Amabile A., Argmann C., Argueta K., Ascolillo S., Bailey R., Batchelor C., Beckmann N.D., Beckmann A.G., Begani P., Berichel J.L., Bogunovic D., Bose S., Bozkus C.C., Bravo P., Buckup M., Burka L., Calorossi S., Cambron L., Carbonell G., Carrara G., Cedillo M.A., Chang C., Chang S., Charney A.W., Chen S.T., Cheng E., Chien J., Chowdhury M., Chung J., Comella P.H., Cosgrove D., Cossarini F., Cotter L., Dave A., Dawson T., Dayal B., Valle DMD, Dhainaut M., Dornfeld R., Dul K., Eaton M., Eber N., Elaiho C., Ellis E., Fabris F., Faith J., Falci D., Feng S., Fennessy B., Fernandes M., Fishman N., Francoeur N.J., Gangadharan S., Geanon D., Gelb B.D., Glicksberg B.S., Gnjatic S., Grabowska J., Gyimesi G., Hamdani M., Handler D., Harris J., Hartnett M., Hatem S., Herbinet M., Herrera E., Hochman A., Hoffman G.E., Hook J., Horta L., Humblin E., Jaladanki S., Jamal H., Johnson J.S., Kang G., Karekar N., Karim S., Kelly G., Kim J., Kim-Schulze S., Kozlova E., Kumar A., Lacunza J., Lansky A., Lebovitch D., Lee B., Lee G., Lee G.H., Lee J., Leech J., Lepow L., Leventhal M.B., Liharska L.E., Lindblad K., Livanos A., Losic B., Machado R., Madrid K., Mahmood Z., Mar K., Marron T.U., Martin G., Marvin R., Maskey S., Matthews P., Meckel K., Mehandru S., Merad M., Mercedes C., Merzier E., Meyer D., Mollaoglu G., Morris S., Mouskas K., Moya E., Yeboah N.A., Nadkarni G., Nie K., Nisenholtz M., Ofori-Amanfo G., Onel K., Ounadjela M., Patel M., Patel V., Pruitt C., Rahman A., Rathi S., Redes J., Reyes-Torres I., Rodrigues A., Rodriguez A., Roudko V., Roussos P., Ruiz E., Scalzo P., Schadt E.E., Scott I., Sebra R., Shah H., Shervey M., Silva P., Simons N.W., Smith M., Soares-Schanoski A., Soto J., Sridhar S.H., Brown S.A., Stefanos H., Straw M., Sweeney R., Tabachnikova A., Teague C., Thompson R., Tin M., Tuballes K., Tyler S.R., Upadhyaya B., Vaid A., Van Der Heide V., Vaninov N., Vlachos K., Wacker D., Walker L., Walsh H., Wang W., Wang B., Wilk C.M., Wilkins L., Wilson K.M., Wilson J., Xie H., Xue L., Yi N., Wang Y.C., Yishak M., Young S., Yu A., Zaks N., Zha R.
ISSN
1542-6416 (Print)
ISSN-L
1542-6416
Statut éditorial
Publié
Date de publication
28/09/2022
Peer-reviewed
Oui
Volume
19
Numéro
1
Pages
34
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Severe COVID-19 leads to important changes in circulating immune-related proteins. To date it has been difficult to understand their temporal relationship and identify cytokines that are drivers of severe COVID-19 outcomes and underlie differences in outcomes between sexes. Here, we measured 147 immune-related proteins during acute COVID-19 to investigate these questions.
We measured circulating protein abundances using the SOMAscan nucleic acid aptamer panel in two large independent hospital-based COVID-19 cohorts in Canada and the United States. We fit generalized additive models with cubic splines from the start of symptom onset to identify protein levels over the first 14 days of infection which were different between severe cases and controls, adjusting for age and sex. Severe cases were defined as individuals with COVID-19 requiring invasive or non-invasive mechanical respiratory support.
580 individuals were included in the analysis. Mean subject age was 64.3 (sd 18.1), and 47% were male. Of the 147 proteins, 69 showed a significant difference between cases and controls (p < 3.4 × 10 <sup>-4</sup> ). Three clusters were formed by 108 highly correlated proteins that replicated in both cohorts, making it difficult to determine which proteins have a true causal effect on severe COVID-19. Six proteins showed sex differences in levels over time, of which 3 were also associated with severe COVID-19: CCL26, IL1RL2, and IL3RA, providing insights to better understand the marked differences in outcomes by sex.
Severe COVID-19 is associated with large changes in 69 immune-related proteins. Further, five proteins were associated with sex differences in outcomes. These results provide direct insights into immune-related proteins that are strongly influenced by severe COVID-19 infection.
Mots-clé
COVID-19, Immunity, Proteomics, SOMAscan
DOI
10.1186/s12014-022-09371-z
Pubmed
36171541
Web of science
000861465600001
Site de l'éditeur
http://europepmc.org/abstract/med/36171541
Open Access
Oui
Création de la notice
09/05/2023 12:59
Dernière modification de la notice
29/11/2024 13:40
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