The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals.

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Serval ID
serval:BIB_EAE845542422
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Production externe
Title
The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals.
Journal
Clinical proteomics
Author(s)
Butler-Laporte G., Gonzalez-Kozlova E., Su C.Y., Zhou S., Nakanishi T., Brunet-Ratnasingham E., Morrison D., Laurent L., Afilalo J., Afilalo M., Henry D., Chen Y., Carrasco-Zanini J., Farjoun Y., Pietzner M., Kimchi N., Afrasiabi Z., Rezk N., Bouab M., Petitjean L., Guzman C., Xue X., Tselios C., Vulesevic B., Adeleye O., Abdullah T., Almamlouk N., Moussa Y., DeLuca C., Duggan N., Schurr E., Brassard N., Durand M., Del Valle D.M., Thompson R., Cedillo M.A., Schadt E., Nie K., Simons N.W., Mouskas K., Zaki N., Patel M., Xie H., Harris J., Marvin R., Cheng E., Tuballes K., Argueta K., Scott I., Greenwood CMT, Paterson C., Hinterberg M., Langenberg C., Forgetta V., Mooser V., Marron T., Beckmann N., Kenigsberg E., Charney A.W., Kim-Schulze S., Merad M., Kaufmann D.E., Gnjatic S., Richards J.B.
Working group(s)
Mount Sinai COVID-19 Biobank Team
Contributor(s)
Agashe C., Agrawal P., Akyatan A., Alesso-Carra K., Alibo E., Alvarez K., Amabile A., Argmann C., Argueta K., Ascolillo S., Bailey R., Batchelor C., Beckmann N.D., Beckmann A.G., Begani P., Berichel J.L., Bogunovic D., Bose S., Bozkus C.C., Bravo P., Buckup M., Burka L., Calorossi S., Cambron L., Carbonell G., Carrara G., Cedillo M.A., Chang C., Chang S., Charney A.W., Chen S.T., Cheng E., Chien J., Chowdhury M., Chung J., Comella P.H., Cosgrove D., Cossarini F., Cotter L., Dave A., Dawson T., Dayal B., Valle DMD, Dhainaut M., Dornfeld R., Dul K., Eaton M., Eber N., Elaiho C., Ellis E., Fabris F., Faith J., Falci D., Feng S., Fennessy B., Fernandes M., Fishman N., Francoeur N.J., Gangadharan S., Geanon D., Gelb B.D., Glicksberg B.S., Gnjatic S., Grabowska J., Gyimesi G., Hamdani M., Handler D., Harris J., Hartnett M., Hatem S., Herbinet M., Herrera E., Hochman A., Hoffman G.E., Hook J., Horta L., Humblin E., Jaladanki S., Jamal H., Johnson J.S., Kang G., Karekar N., Karim S., Kelly G., Kim J., Kim-Schulze S., Kozlova E., Kumar A., Lacunza J., Lansky A., Lebovitch D., Lee B., Lee G., Lee G.H., Lee J., Leech J., Lepow L., Leventhal M.B., Liharska L.E., Lindblad K., Livanos A., Losic B., Machado R., Madrid K., Mahmood Z., Mar K., Marron T.U., Martin G., Marvin R., Maskey S., Matthews P., Meckel K., Mehandru S., Merad M., Mercedes C., Merzier E., Meyer D., Mollaoglu G., Morris S., Mouskas K., Moya E., Yeboah N.A., Nadkarni G., Nie K., Nisenholtz M., Ofori-Amanfo G., Onel K., Ounadjela M., Patel M., Patel V., Pruitt C., Rahman A., Rathi S., Redes J., Reyes-Torres I., Rodrigues A., Rodriguez A., Roudko V., Roussos P., Ruiz E., Scalzo P., Schadt E.E., Scott I., Sebra R., Shah H., Shervey M., Silva P., Simons N.W., Smith M., Soares-Schanoski A., Soto J., Sridhar S.H., Brown S.A., Stefanos H., Straw M., Sweeney R., Tabachnikova A., Teague C., Thompson R., Tin M., Tuballes K., Tyler S.R., Upadhyaya B., Vaid A., Van Der Heide V., Vaninov N., Vlachos K., Wacker D., Walker L., Walsh H., Wang W., Wang B., Wilk C.M., Wilkins L., Wilson K.M., Wilson J., Xie H., Xue L., Yi N., Wang Y.C., Yishak M., Young S., Yu A., Zaks N., Zha R.
ISSN
1542-6416 (Print)
ISSN-L
1542-6416
Publication state
Published
Issued date
28/09/2022
Peer-reviewed
Oui
Volume
19
Number
1
Pages
34
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Severe COVID-19 leads to important changes in circulating immune-related proteins. To date it has been difficult to understand their temporal relationship and identify cytokines that are drivers of severe COVID-19 outcomes and underlie differences in outcomes between sexes. Here, we measured 147 immune-related proteins during acute COVID-19 to investigate these questions.
We measured circulating protein abundances using the SOMAscan nucleic acid aptamer panel in two large independent hospital-based COVID-19 cohorts in Canada and the United States. We fit generalized additive models with cubic splines from the start of symptom onset to identify protein levels over the first 14 days of infection which were different between severe cases and controls, adjusting for age and sex. Severe cases were defined as individuals with COVID-19 requiring invasive or non-invasive mechanical respiratory support.
580 individuals were included in the analysis. Mean subject age was 64.3 (sd 18.1), and 47% were male. Of the 147 proteins, 69 showed a significant difference between cases and controls (p < 3.4 × 10 <sup>-4</sup> ). Three clusters were formed by 108 highly correlated proteins that replicated in both cohorts, making it difficult to determine which proteins have a true causal effect on severe COVID-19. Six proteins showed sex differences in levels over time, of which 3 were also associated with severe COVID-19: CCL26, IL1RL2, and IL3RA, providing insights to better understand the marked differences in outcomes by sex.
Severe COVID-19 is associated with large changes in 69 immune-related proteins. Further, five proteins were associated with sex differences in outcomes. These results provide direct insights into immune-related proteins that are strongly influenced by severe COVID-19 infection.
Keywords
COVID-19, Immunity, Proteomics, SOMAscan
DOI
10.1186/s12014-022-09371-z
Pubmed
36171541
Web of science
000861465600001
Publisher's website
http://europepmc.org/abstract/med/36171541
Open Access
Yes
Create date
09/05/2023 12:59
Last modification date
29/11/2024 13:40
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