Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma.

Détails

ID Serval
serval:BIB_EA366326EF67
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma.
Périodique
Cancer cell
Auteur(s)
Zheng S., Cherniack A.D., Dewal N., Moffitt R.A., Danilova L., Murray B.A., Lerario A.M., Else T., Knijnenburg T.A., Ciriello G., Kim S., Assie G., Morozova O., Akbani R., Shih J., Hoadley K.A., Choueiri T.K., Waldmann J., Mete O., Robertson A.G., Wu H.T., Raphael B.J., Shao L., Meyerson M., Demeure M.J., Beuschlein F., Gill A.J., Sidhu S.B., Almeida M.Q., Fragoso M.C., Cope L.M., Kebebew E., Habra M.A., Whitsett T.G., Bussey K.J., Rainey W.E., Asa S.L., Bertherat J., Fassnacht M., Wheeler D.A., Hammer G.D., Giordano T.J., Verhaak R.G.
Collaborateur(s)
Cancer Genome Atlas Research Network
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Statut éditorial
Publié
Date de publication
09/04/2016
Peer-reviewed
Oui
Volume
29
Numéro
5
Pages
723-736
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
We describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers.

Mots-clé
Adolescent, Adrenal Cortex Neoplasms/genetics, Adrenal Cortex Neoplasms/pathology, Adrenal Cortex Neoplasms/therapy, Adrenocortical Carcinoma/genetics, Adrenocortical Carcinoma/pathology, Adrenocortical Carcinoma/therapy, Adult, Aged, Aged, 80 and over, Child, DNA Methylation, Disease-Free Survival, Female, Gene Expression Profiling/methods, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease/genetics, Genome, Human/genetics, Genomics/methods, Humans, Male, Middle Aged, Mutation, Outcome Assessment (Health Care), Prognosis, Young Adult
Pubmed
Open Access
Oui
Création de la notice
11/04/2017 19:24
Dernière modification de la notice
21/08/2019 6:34
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