Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma.

Details

Serval ID
serval:BIB_EA366326EF67
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma.
Journal
Cancer cell
Author(s)
Zheng S., Cherniack A.D., Dewal N., Moffitt R.A., Danilova L., Murray B.A., Lerario A.M., Else T., Knijnenburg T.A., Ciriello G., Kim S., Assie G., Morozova O., Akbani R., Shih J., Hoadley K.A., Choueiri T.K., Waldmann J., Mete O., Robertson A.G., Wu H.T., Raphael B.J., Shao L., Meyerson M., Demeure M.J., Beuschlein F., Gill A.J., Sidhu S.B., Almeida M.Q., Fragoso M.C., Cope L.M., Kebebew E., Habra M.A., Whitsett T.G., Bussey K.J., Rainey W.E., Asa S.L., Bertherat J., Fassnacht M., Wheeler D.A., Hammer G.D., Giordano T.J., Verhaak R.G.
Working group(s)
Cancer Genome Atlas Research Network
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Publication state
Published
Issued date
09/04/2016
Peer-reviewed
Oui
Volume
29
Number
5
Pages
723-736
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
We describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers.

Keywords
Adolescent, Adrenal Cortex Neoplasms/genetics, Adrenal Cortex Neoplasms/pathology, Adrenal Cortex Neoplasms/therapy, Adrenocortical Carcinoma/genetics, Adrenocortical Carcinoma/pathology, Adrenocortical Carcinoma/therapy, Adult, Aged, Aged, 80 and over, Child, DNA Methylation, Disease-Free Survival, Female, Gene Expression Profiling/methods, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease/genetics, Genome, Human/genetics, Genomics/methods, Humans, Male, Middle Aged, Mutation, Outcome Assessment (Health Care), Prognosis, Young Adult
Pubmed
Open Access
Yes
Create date
11/04/2017 18:24
Last modification date
21/08/2019 5:34
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