No association between ApoE polymorphism and febrile seizures.

Détails

Ressource 1Demande d'une copie Sous embargo indéterminé.
Accès restreint UNIL
Etat: Public
Version: de l'auteur⸱e
Licence: Non spécifiée
ID Serval
serval:BIB_E8F6DEC81E18
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
No association between ApoE polymorphism and febrile seizures.
Périodique
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Auteur⸱e⸱s
Lavenex P., Lavenex P.B., Cachat F., Gehri M., Juvet T.
ISSN
1590-3478 (Electronic)
ISSN-L
1590-1874
Statut éditorial
Publié
Date de publication
01/2016
Peer-reviewed
Oui
Volume
37
Numéro
1
Pages
31-36
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Seizures associated with fever are a common pediatric problem, affecting about 2-7 % of children between 3 months and 5 years of age. Differentiation of febrile seizures from acute symptomatic seizures secondary to central nervous system infections or seizures associated with fever in children with epilepsy is essential to provide appropriate treatment and follow-up care. Here, we tested the hypothesis that children who exhibit simple febrile seizures during early childhood, but do not develop epileptic seizures later in life, might preferentially carry the ApoE2 allele of the gene coding for the apolipoprotein E. We did not find any differences in the distribution of ApoE alleles or genotypes between individuals who exhibited simple febrile seizures (n = 93) and age-matched, typically developing subjects (n = 80). We found that the observed allele and genotype frequencies did not deviate from Hardy-Weinberg equilibrium, which suggests that the frequencies of ApoE alleles and genotypes are stable in the Swiss population from which our samples were derived. Across both groups of subjects (n = 173), we found an ApoE2 allele frequency of 0.064, an ApoE3 frequency of 0.829 and an ApoE4 frequency of 0.107. Our findings are consistent with previous reports of the distribution of ApoE polymorphism for European subjects free of any neurological disorders, and show that the different alleles of the gene coding for the apolipoprotein E are not associated with the occurrence of simple febrile seizures.
Mots-clé
Apolipoproteins E/genetics, Child, Child, Preschool, European Continental Ancestry Group/genetics, Female, Follow-Up Studies, Gene Frequency, Genotyping Techniques, Humans, Infant, Male, Odds Ratio, Polymorphism, Genetic, Seizures, Febrile/genetics, Seizures, Febrile/therapy, Switzerland
Pubmed
Création de la notice
19/09/2015 18:35
Dernière modification de la notice
13/10/2021 5:42
Données d'usage