No association between ApoE polymorphism and febrile seizures.

Details

Serval ID
serval:BIB_E8F6DEC81E18
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
No association between ApoE polymorphism and febrile seizures.
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Author(s)
Lavenex P., Lavenex P.B., Cachat F., Gehri M., Juvet T.
ISSN
1590-3478 (Electronic)
ISSN-L
1590-1874
Publication state
Published
Issued date
01/2016
Peer-reviewed
Oui
Volume
37
Number
1
Pages
31-36
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Seizures associated with fever are a common pediatric problem, affecting about 2-7 % of children between 3 months and 5 years of age. Differentiation of febrile seizures from acute symptomatic seizures secondary to central nervous system infections or seizures associated with fever in children with epilepsy is essential to provide appropriate treatment and follow-up care. Here, we tested the hypothesis that children who exhibit simple febrile seizures during early childhood, but do not develop epileptic seizures later in life, might preferentially carry the ApoE2 allele of the gene coding for the apolipoprotein E. We did not find any differences in the distribution of ApoE alleles or genotypes between individuals who exhibited simple febrile seizures (n = 93) and age-matched, typically developing subjects (n = 80). We found that the observed allele and genotype frequencies did not deviate from Hardy-Weinberg equilibrium, which suggests that the frequencies of ApoE alleles and genotypes are stable in the Swiss population from which our samples were derived. Across both groups of subjects (n = 173), we found an ApoE2 allele frequency of 0.064, an ApoE3 frequency of 0.829 and an ApoE4 frequency of 0.107. Our findings are consistent with previous reports of the distribution of ApoE polymorphism for European subjects free of any neurological disorders, and show that the different alleles of the gene coding for the apolipoprotein E are not associated with the occurrence of simple febrile seizures.

Keywords
Apolipoproteins E/genetics, Child, Child, Preschool, European Continental Ancestry Group/genetics, Female, Follow-Up Studies, Gene Frequency, Genotyping Techniques, Humans, Infant, Male, Odds Ratio, Polymorphism, Genetic, Seizures, Febrile/genetics, Seizures, Febrile/therapy, Switzerland
Pubmed
Create date
19/09/2015 18:35
Last modification date
20/08/2019 16:11
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