When less is more: sketching with minimizers in genomics.

Détails

ID Serval
serval:BIB_E86014EEAF89
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
When less is more: sketching with minimizers in genomics.
Périodique
Genome biology
Auteur⸱e⸱s
Ndiaye M., Prieto-Baños S., Fitzgerald L.M., Yazdizadeh Kharrazi A., Oreshkov S., Dessimoz C., Sedlazeck F.J., Glover N., Majidian S.
ISSN
1474-760X (Electronic)
ISSN-L
1474-7596
Statut éditorial
Publié
Date de publication
14/10/2024
Peer-reviewed
Oui
Volume
25
Numéro
1
Pages
270
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
The exponential increase in sequencing data calls for conceptual and computational advances to extract useful biological insights. One such advance, minimizers, allows for reducing the quantity of data handled while maintaining some of its key properties. We provide a basic introduction to minimizers, cover recent methodological developments, and review the diverse applications of minimizers to analyze genomic data, including de novo genome assembly, metagenomics, read alignment, read correction, and pangenomes. We also touch on alternative data sketching techniques including universal hitting sets, syncmers, or strobemers. Minimizers and their alternatives have rapidly become indispensable tools for handling vast amounts of data.
Mots-clé
Genomics/methods, Metagenomics/methods, Humans, Software
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/10/2024 8:39
Dernière modification de la notice
02/11/2024 7:10
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