When less is more: sketching with minimizers in genomics.
Details
Serval ID
serval:BIB_E86014EEAF89
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
When less is more: sketching with minimizers in genomics.
Journal
Genome biology
ISSN
1474-760X (Electronic)
ISSN-L
1474-7596
Publication state
Published
Issued date
14/10/2024
Peer-reviewed
Oui
Volume
25
Number
1
Pages
270
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Abstract
The exponential increase in sequencing data calls for conceptual and computational advances to extract useful biological insights. One such advance, minimizers, allows for reducing the quantity of data handled while maintaining some of its key properties. We provide a basic introduction to minimizers, cover recent methodological developments, and review the diverse applications of minimizers to analyze genomic data, including de novo genome assembly, metagenomics, read alignment, read correction, and pangenomes. We also touch on alternative data sketching techniques including universal hitting sets, syncmers, or strobemers. Minimizers and their alternatives have rapidly become indispensable tools for handling vast amounts of data.
Keywords
Genomics/methods, Metagenomics/methods, Humans, Software
Pubmed
Web of science
Open Access
Yes
Create date
25/10/2024 8:39
Last modification date
02/11/2024 7:10