Interstitial fluid pressure: A novel biomarker to monitor photo-induced drug uptake in tumor and normal tissues.
Détails
ID Serval
serval:BIB_E7ED9CE389BA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Interstitial fluid pressure: A novel biomarker to monitor photo-induced drug uptake in tumor and normal tissues.
Périodique
Lasers in surgery and medicine
ISSN
1096-9101 (Electronic)
ISSN-L
0196-8092
Statut éditorial
Publié
Date de publication
10/2017
Peer-reviewed
Oui
Volume
49
Numéro
8
Pages
773-780
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Low-dose photodynamic therapy PDT (photoinduction) can modulate tumor vessels and enhance the uptake of liposomal cisplatin (Lipoplatin®) in pleural malignancies. However, the photo-induction conditions must be tightly controlled as overtreatment shuts down tumor vessels and enhances normal tissue drug uptake.
In a pleural sarcoma and adenocarcinoma rat model (n = 12/group), we applied photoinduction (0.0625 mg/kg Visudyne®, 10 J/cm <sup>2</sup> ) followed by intravenous Lipoplatin® (5 mg/kg) administration. Tumor and normal tissue IFP were assessed before and up to 1 hour following photoinduction. Lipoplatin® uptake was determined 60 minutes following photoinduction. We then treated the pleura of tumor-free minipigs with high dose photodynamic therapy (PDT) (0.0625 mg/kg Visudyne®, 30 J/cm <sup>2</sup> , n = 5) followed by Lipoplatin (5 mg/kg) administration.
In rodents, photoinduction resulted in a significant decrease of IFP (P < 0.05) in both tumor types but not in the surrounding normal lung, equally exposed to light. Also, photoinduction resulted in a significant increase of Lipoplatin® uptake in both tumor types (P < 0.05) but not in normal lung. Tumor IFP variation and Lipoplatin® uptake fitted an inverted parabola. In minipigs, high dose photodynamic treatment resulted in pleural IFP increase of some animals which predicted higher Lipoplatin® uptake levels.
Normal and tumor vasculatures react differently to PDT. Continuous IFP monitoring in normal and tumor tissues is a promising biomarker of vessel photoinduction. Moderate drop in tumor with no change in normal tissue IFP are predictive of specific Lipoplatin® uptake by cancer following PDT. Lasers Surg. Med. 49:773-780, 2017. © 2017 Wiley Periodicals, Inc.
In a pleural sarcoma and adenocarcinoma rat model (n = 12/group), we applied photoinduction (0.0625 mg/kg Visudyne®, 10 J/cm <sup>2</sup> ) followed by intravenous Lipoplatin® (5 mg/kg) administration. Tumor and normal tissue IFP were assessed before and up to 1 hour following photoinduction. Lipoplatin® uptake was determined 60 minutes following photoinduction. We then treated the pleura of tumor-free minipigs with high dose photodynamic therapy (PDT) (0.0625 mg/kg Visudyne®, 30 J/cm <sup>2</sup> , n = 5) followed by Lipoplatin (5 mg/kg) administration.
In rodents, photoinduction resulted in a significant decrease of IFP (P < 0.05) in both tumor types but not in the surrounding normal lung, equally exposed to light. Also, photoinduction resulted in a significant increase of Lipoplatin® uptake in both tumor types (P < 0.05) but not in normal lung. Tumor IFP variation and Lipoplatin® uptake fitted an inverted parabola. In minipigs, high dose photodynamic treatment resulted in pleural IFP increase of some animals which predicted higher Lipoplatin® uptake levels.
Normal and tumor vasculatures react differently to PDT. Continuous IFP monitoring in normal and tumor tissues is a promising biomarker of vessel photoinduction. Moderate drop in tumor with no change in normal tissue IFP are predictive of specific Lipoplatin® uptake by cancer following PDT. Lasers Surg. Med. 49:773-780, 2017. © 2017 Wiley Periodicals, Inc.
Mots-clé
Adenocarcinoma/drug therapy, Adenocarcinoma/metabolism, Animals, Antineoplastic Agents/pharmacokinetics, Antineoplastic Agents/therapeutic use, Biomarkers, Cell Line, Tumor, Cisplatin/pharmacokinetics, Cisplatin/therapeutic use, Extracellular Fluid/physiology, Injections, Intravenous, Male, Photochemotherapy/methods, Photosensitizing Agents/therapeutic use, Pleural Neoplasms/drug therapy, Pleural Neoplasms/metabolism, Porphyrins/therapeutic use, Pressure, Rats, Rats, Inbred F344, Sarcoma/drug therapy, Sarcoma/metabolism, Swine, Lipoplatin®, biomarker, interstitial fluid pressure, photodynamic therapy, pleural malignancies, thoracoscopy
Pubmed
Web of science
Création de la notice
13/10/2017 17:20
Dernière modification de la notice
29/06/2023 7:51