Interstitial fluid pressure: A novel biomarker to monitor photo-induced drug uptake in tumor and normal tissues.

Details

Serval ID
serval:BIB_E7ED9CE389BA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interstitial fluid pressure: A novel biomarker to monitor photo-induced drug uptake in tumor and normal tissues.
Journal
Lasers in surgery and medicine
Author(s)
Cavin S., Wang X., Zellweger M., Gonzalez M., Bensimon M., Wagnières G., Krueger T., Ris H.B., Gronchi F., Perentes J.Y.
ISSN
1096-9101 (Electronic)
ISSN-L
0196-8092
Publication state
Published
Issued date
10/2017
Peer-reviewed
Oui
Volume
49
Number
8
Pages
773-780
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Low-dose photodynamic therapy PDT (photoinduction) can modulate tumor vessels and enhance the uptake of liposomal cisplatin (Lipoplatin®) in pleural malignancies. However, the photo-induction conditions must be tightly controlled as overtreatment shuts down tumor vessels and enhances normal tissue drug uptake.
In a pleural sarcoma and adenocarcinoma rat model (n = 12/group), we applied photoinduction (0.0625 mg/kg Visudyne®, 10 J/cm <sup>2</sup> ) followed by intravenous Lipoplatin® (5 mg/kg) administration. Tumor and normal tissue IFP were assessed before and up to 1 hour following photoinduction. Lipoplatin® uptake was determined 60 minutes following photoinduction. We then treated the pleura of tumor-free minipigs with high dose photodynamic therapy (PDT) (0.0625 mg/kg Visudyne®, 30 J/cm <sup>2</sup> , n = 5) followed by Lipoplatin (5 mg/kg) administration.
In rodents, photoinduction resulted in a significant decrease of IFP (P < 0.05) in both tumor types but not in the surrounding normal lung, equally exposed to light. Also, photoinduction resulted in a significant increase of Lipoplatin® uptake in both tumor types (P < 0.05) but not in normal lung. Tumor IFP variation and Lipoplatin® uptake fitted an inverted parabola. In minipigs, high dose photodynamic treatment resulted in pleural IFP increase of some animals which predicted higher Lipoplatin® uptake levels.
Normal and tumor vasculatures react differently to PDT. Continuous IFP monitoring in normal and tumor tissues is a promising biomarker of vessel photoinduction. Moderate drop in tumor with no change in normal tissue IFP are predictive of specific Lipoplatin® uptake by cancer following PDT. Lasers Surg. Med. 49:773-780, 2017. © 2017 Wiley Periodicals, Inc.
Keywords
Adenocarcinoma/drug therapy, Adenocarcinoma/metabolism, Animals, Antineoplastic Agents/pharmacokinetics, Antineoplastic Agents/therapeutic use, Biomarkers, Cell Line, Tumor, Cisplatin/pharmacokinetics, Cisplatin/therapeutic use, Extracellular Fluid/physiology, Injections, Intravenous, Male, Photochemotherapy/methods, Photosensitizing Agents/therapeutic use, Pleural Neoplasms/drug therapy, Pleural Neoplasms/metabolism, Porphyrins/therapeutic use, Pressure, Rats, Rats, Inbred F344, Sarcoma/drug therapy, Sarcoma/metabolism, Swine, Lipoplatin®, biomarker, interstitial fluid pressure, photodynamic therapy, pleural malignancies, thoracoscopy
Pubmed
Web of science
Create date
13/10/2017 16:20
Last modification date
20/08/2019 16:10
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