Immunotherapy opportunities in ovarian cancer.

Détails

ID Serval
serval:BIB_E79733FB5F41
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Immunotherapy opportunities in ovarian cancer.
Périodique
Expert Review of Anticancer Therapy
Auteur(s)
Chu C.S., Kim S.H., June C.H., Coukos G.
ISSN
1744-8328 (Electronic)
ISSN-L
1473-7140
Statut éditorial
Publié
Date de publication
2008
Volume
8
Numéro
2
Pages
243-257
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
Ovarian cancer is responsible for the majority of gynecologic cancer deaths and despite the highest standard of multimodality therapy with surgery and cytotoxic chemotherapy, long-term survival remains low. With compelling evidence that epithelial ovarian cancer is an immunogenic tumor capable of stimulating an antitumor immune response, renewed efforts to develop immune therapies to augment the efficacy of traditional therapies are underway. Current immunotherapies focus on varied modes of antitumor vaccine development, particularly with the use of dendritic cell vaccines, effective methods for adoptive T-cell transfer and combinatorial approaches with immune modulatory therapy subverting natural tolerance mechanisms or boosting effector mechanisms. Additional combinatorial approaches include the use of cytokines and/or chemotherapy with immune therapy.
Mots-clé
Cancer Vaccines/therapeutic use, Chemotherapy, Adjuvant, Clinical Trials as Topic, Combined Modality Therapy, Female, Humans, Immunotherapy/methods, Immunotherapy, Adoptive, Killer Cells, Natural/immunology, Neoplasms, Glandular and Epithelial/immunology, Neoplasms, Glandular and Epithelial/mortality, Ovarian Neoplasms/immunology, Ovarian Neoplasms/mortality, Ovariectomy/methods, Prognosis, Risk Assessment, Survival Analysis, Time Factors, Treatment Outcome, Tumor Escape/immunology
Pubmed
Création de la notice
14/10/2014 11:43
Dernière modification de la notice
20/08/2019 16:10
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