Immunotherapy opportunities in ovarian cancer.

Details

Serval ID
serval:BIB_E79733FB5F41
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Immunotherapy opportunities in ovarian cancer.
Journal
Expert Review of Anticancer Therapy
Author(s)
Chu C.S., Kim S.H., June C.H., Coukos G.
ISSN
1744-8328 (Electronic)
ISSN-L
1473-7140
Publication state
Published
Issued date
2008
Volume
8
Number
2
Pages
243-257
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
Ovarian cancer is responsible for the majority of gynecologic cancer deaths and despite the highest standard of multimodality therapy with surgery and cytotoxic chemotherapy, long-term survival remains low. With compelling evidence that epithelial ovarian cancer is an immunogenic tumor capable of stimulating an antitumor immune response, renewed efforts to develop immune therapies to augment the efficacy of traditional therapies are underway. Current immunotherapies focus on varied modes of antitumor vaccine development, particularly with the use of dendritic cell vaccines, effective methods for adoptive T-cell transfer and combinatorial approaches with immune modulatory therapy subverting natural tolerance mechanisms or boosting effector mechanisms. Additional combinatorial approaches include the use of cytokines and/or chemotherapy with immune therapy.
Keywords
Cancer Vaccines/therapeutic use, Chemotherapy, Adjuvant, Clinical Trials as Topic, Combined Modality Therapy, Female, Humans, Immunotherapy/methods, Immunotherapy, Adoptive, Killer Cells, Natural/immunology, Neoplasms, Glandular and Epithelial/immunology, Neoplasms, Glandular and Epithelial/mortality, Ovarian Neoplasms/immunology, Ovarian Neoplasms/mortality, Ovariectomy/methods, Prognosis, Risk Assessment, Survival Analysis, Time Factors, Treatment Outcome, Tumor Escape/immunology
Pubmed
Create date
14/10/2014 11:43
Last modification date
20/08/2019 16:10
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