Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults.

Détails

Ressource 1Télécharger: Serval_PostPrint_2013_Skeletal muscle mitochondria energetics are associated with maximal aerobic capacity and walking speed in older adults.pdf (581.08 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_E74D1A0F7881
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults.
Périodique
Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Auteur(s)
Coen P.M., Jubrias S.A., Distefano G., Amati F., Mackey D.C., Glynn N.W., Manini T.M., Wohlgemuth S.E., Leeuwenburgh C., Cummings S.R., Newman A.B., Ferrucci L., Toledo F.G., Shankland E., Conley K.E., Goodpaster B.H.
ISSN
1758-535X (Electronic)
ISSN-L
1079-5006
Statut éditorial
Publié
Date de publication
04/2013
Peer-reviewed
Oui
Volume
68
Numéro
4
Pages
447-455
Langue
anglais
Notes
Publication types: Journal Article
Résumé
BACKGROUND: Lower ambulatory performance with aging may be related to a reduced oxidative capacity within skeletal muscle. This study examined the associations between skeletal muscle mitochondrial capacity and efficiency with walking performance in a group of older adults.
METHODS: Thirty-seven older adults (mean age 78 years; 21 men and 16 women) completed an aerobic capacity (VO peak) test and measurement of preferred walking speed over 400 m. Maximal coupled (State 3; St3) mitochondrial respiration was determined by high-resolution respirometry in saponin-permeabilized myofibers obtained from percutanous biopsies of vastus lateralis (n = 22). Maximal phosphorylation capacity (ATP) of vastus lateralis was determined in vivo by P magnetic resonance spectroscopy (n = 30). Quadriceps contractile volume was determined by magnetic resonance imaging. Mitochondrial efficiency (max ATP production/max O consumption) was characterized using ATP per St3 respiration (ATP/St3).
RESULTS: In vitro St3 respiration was significantly correlated with in vivo ATP (r = .47, p = .004). Total oxidative capacity of the quadriceps (St3*quadriceps contractile volume) was a determinant of VO peak (r = .33, p = .006). ATP (r = .158, p = .03) and VO peak (r = .475, p < .0001) were correlated with preferred walking speed. Inclusion of both ATP/St3 and VO peak in a multiple linear regression model improved the prediction of preferred walking speed (r = .647, p < .0001), suggesting that mitochondrial efficiency is an important determinant for preferred walking speed.
CONCLUSIONS: Lower mitochondrial capacity and efficiency were both associated with slower walking speed within a group of older participants with a wide range of function. In addition to aerobic capacity, lower mitochondrial capacity and efficiency likely play roles in slowing gait speed with age.
Pubmed
Web of science
Open Access
Oui
Financement(s)
Fonds national suisse / Carrières / PZ00P3-126339
Création de la notice
07/04/2013 16:42
Dernière modification de la notice
20/01/2020 7:10
Données d'usage