Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_E74D1A0F7881
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults.
Journal
Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Author(s)
Coen P.M., Jubrias S.A., Distefano G., Amati F., Mackey D.C., Glynn N.W., Manini T.M., Wohlgemuth S.E., Leeuwenburgh C., Cummings S.R., Newman A.B., Ferrucci L., Toledo F.G., Shankland E., Conley K.E., Goodpaster B.H.
ISSN
1758-535X (Electronic)
ISSN-L
1079-5006
Publication state
Published
Issued date
04/2013
Peer-reviewed
Oui
Volume
68
Number
4
Pages
447-455
Language
english
Notes
Publication types: Journal Article
Abstract
BACKGROUND: Lower ambulatory performance with aging may be related to a reduced oxidative capacity within skeletal muscle. This study examined the associations between skeletal muscle mitochondrial capacity and efficiency with walking performance in a group of older adults.
METHODS: Thirty-seven older adults (mean age 78 years; 21 men and 16 women) completed an aerobic capacity (VO peak) test and measurement of preferred walking speed over 400 m. Maximal coupled (State 3; St3) mitochondrial respiration was determined by high-resolution respirometry in saponin-permeabilized myofibers obtained from percutanous biopsies of vastus lateralis (n = 22). Maximal phosphorylation capacity (ATP) of vastus lateralis was determined in vivo by P magnetic resonance spectroscopy (n = 30). Quadriceps contractile volume was determined by magnetic resonance imaging. Mitochondrial efficiency (max ATP production/max O consumption) was characterized using ATP per St3 respiration (ATP/St3).
RESULTS: In vitro St3 respiration was significantly correlated with in vivo ATP (r = .47, p = .004). Total oxidative capacity of the quadriceps (St3*quadriceps contractile volume) was a determinant of VO peak (r = .33, p = .006). ATP (r = .158, p = .03) and VO peak (r = .475, p < .0001) were correlated with preferred walking speed. Inclusion of both ATP/St3 and VO peak in a multiple linear regression model improved the prediction of preferred walking speed (r = .647, p < .0001), suggesting that mitochondrial efficiency is an important determinant for preferred walking speed.
CONCLUSIONS: Lower mitochondrial capacity and efficiency were both associated with slower walking speed within a group of older participants with a wide range of function. In addition to aerobic capacity, lower mitochondrial capacity and efficiency likely play roles in slowing gait speed with age.
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / PZ00P3-126339
Create date
07/04/2013 16:42
Last modification date
20/01/2020 7:10
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