Genome-wide association study identifies 48 common genetic variants associated with handedness.

Cuellar-Partida, G.; Tung, J.Y.; Eriksson, N.; Albrecht, E.; Aliev, F.; Andreassen, O.A.; Barroso, I.; Beckmann, J.S.; Boks, M.P.; Boomsma, D.I.; Boyd, H.A.; Breteler, MMB; Campbell, H.; Chasman, D.I.; Cherkas, L.F.; Davies, G.; de Geus, EJC; Deary, I.J.; Deloukas, P.; Dick, D.M.; Duffy, D.L.; Eriksson, J.G.; Esko, T.; Feenstra, B.; Geller, F.; Gieger, C.; Giegling, I.; Gordon, S.D.; Han, J.; Hansen, T.F.; Hartmann, A.M.; Hayward, C.; Heikkilä, K.; Hicks, A.A.; Hirschhorn, J.N.; Hottenga, J.J.; Huffman, J.E.; Hwang, L.D.; Ikram, M.A.; Kaprio, J.; Kemp, J.P.; Khaw, K.T.; Klopp, N.; Konte, B.; Kutalik, Z.; Lahti, J.; Li, X.; Loos, RJF; Luciano, M.; Magnusson, S.H.; Mangino, M.; Marques-Vidal, P.; Martin, N.G.; McArdle, W.L.; McCarthy, M.I.; Medina-Gomez, C.; Melbye, M.; Melville, S.A.; Metspalu, A.; Milani, L.; Mooser, V.; Nelis, M.; Nyholt, D.R.; O'Connell, K.S.; Ophoff, R.A.; Palmer, C.; Palotie, A.; Palviainen, T.; Pare, G.; Paternoster, L.; Peltonen, L.; Penninx, BWJH; Polasek, O.; Pramstaller, P.P.; Prokopenko, I.; Raikkonen, K.; Ripatti, S.; Rivadeneira, F.; Rudan, I.; Rujescu, D.; Smit, J.H.; Smith, G.D.; Smoller, J.W.; Soranzo, N.; Spector, T.D.; Pourcain, B.S.; Starr, J.M.; Stefánsson, H.; Steinberg, S.; Teder-Laving, M.; Thorleifsson, G.; Stefánsson, K.; Timpson, N.J.; Uitterlinden, A.G.; van Duijn, C.M.; van Rooij, FJA; Vink, J.M.; Vollenweider, P.; Vuoksimaa, E.; Waeber, G.; Wareham, N.J.; Warrington, N.; Waterworth, D.; Werge, T.; Wichmann, H.E.; Widen, E.; Willemsen, G.; Wright, A.F.; Wright, M.J.; Xu, M.; Zhao, J.H.; Kraft, P.; Hinds, D.A.; Lindgren, C.M.; Mägi, R.; Neale, B.M.; Evans, D.M.; Medland, S.E.

doi:10.1038/s41562-020-00956-y

Genome-wide association study identifies 48 common genetic variants associated with handedness.

Détails

Télécharger: Cuellar.pdf (969.12 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: CC BY 4.0

Document(s) secondaire(s)

Télécharger: Cuellar_1.xlsx (1098.90 [Ko])
Etat: Public
Version: Supplementary document
Licence: Non spécifiée

ID Serval

serval:BIB_E7424914D13E

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

Genome-wide association study identifies 48 common genetic variants associated with handedness.

Périodique

Nature human behaviour

Auteur⸱e⸱s

Cuellar-Partida G., Tung J.Y., Eriksson N., Albrecht E., Aliev F., Andreassen O.A., Barroso I., Beckmann J.S., Boks M.P., Boomsma D.I., Boyd H.A., Breteler MMB, Campbell H., Chasman D.I., Cherkas L.F., Davies G., de Geus EJC, Deary I.J., Deloukas P., Dick D.M., Duffy D.L., Eriksson J.G., Esko T., Feenstra B., Geller F., Gieger C., Giegling I., Gordon S.D., Han J., Hansen T.F., Hartmann A.M., Hayward C., Heikkilä K., Hicks A.A., Hirschhorn J.N., Hottenga J.J., Huffman J.E., Hwang L.D., Ikram M.A., Kaprio J., Kemp J.P., Khaw K.T., Klopp N., Konte B., Kutalik Z., Lahti J., Li X., Loos RJF, Luciano M., Magnusson S.H., Mangino M., Marques-Vidal P., Martin N.G., McArdle W.L., McCarthy M.I., Medina-Gomez C., Melbye M., Melville S.A., Metspalu A., Milani L., Mooser V., Nelis M., Nyholt D.R., O'Connell K.S., Ophoff R.A., Palmer C., Palotie A., Palviainen T., Pare G., Paternoster L., Peltonen L., Penninx BWJH, Polasek O., Pramstaller P.P., Prokopenko I., Raikkonen K., Ripatti S., Rivadeneira F., Rudan I., Rujescu D., Smit J.H., Smith G.D., Smoller J.W., Soranzo N., Spector T.D., Pourcain B.S., Starr J.M., Stefánsson H., Steinberg S., Teder-Laving M., Thorleifsson G., Stefánsson K., Timpson N.J., Uitterlinden A.G., van Duijn C.M., van Rooij FJA, Vink J.M., Vollenweider P., Vuoksimaa E., Waeber G., Wareham N.J., Warrington N., Waterworth D., Werge T., Wichmann H.E., Widen E., Willemsen G., Wright A.F., Wright M.J., Xu M., Zhao J.H., Kraft P., Hinds D.A., Lindgren C.M., Mägi R., Neale B.M., Evans D.M., Medland S.E.

ISSN

2397-3374 (Electronic)

ISSN-L

2397-3374

Statut éditorial

Publié

Date de publication

01/2021

Peer-reviewed

Oui

Volume

Numéro

Pages

59-70

Langue

anglais

Notes

Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Résumé

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10 <sup>-8</sup> ) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (r <sub>G</sub> = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.

Mots-clé

Adult, Aged, Female, Functional Laterality/genetics, Gene Frequency/genetics, Genetic Loci/genetics, Genetic Variation/genetics, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Single Nucleotide/genetics, Quantitative Trait, Heritable, Sex Factors

URN

urn:nbn:ch:serval-BIB_E7424914D13E8

OAI-PMH

oai:serval.unil.ch:BIB_E7424914D13E

DOI

10.1038/s41562-020-00956-y

Pubmed

32989287

Web of science

000573450500001

Création de la notice

05/10/2020 13:00