Genome-wide association study identifies 48 common genetic variants associated with handedness.

Details

Serval ID
serval:BIB_E7424914D13E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-wide association study identifies 48 common genetic variants associated with handedness.
Journal
Nature human behaviour
Author(s)
Cuellar-Partida G., Tung J.Y., Eriksson N., Albrecht E., Aliev F., Andreassen O.A., Barroso I., Beckmann J.S., Boks M.P., Boomsma D.I., Boyd H.A., Breteler MMB, Campbell H., Chasman D.I., Cherkas L.F., Davies G., de Geus EJC, Deary I.J., Deloukas P., Dick D.M., Duffy D.L., Eriksson J.G., Esko T., Feenstra B., Geller F., Gieger C., Giegling I., Gordon S.D., Han J., Hansen T.F., Hartmann A.M., Hayward C., Heikkilä K., Hicks A.A., Hirschhorn J.N., Hottenga J.J., Huffman J.E., Hwang L.D., Ikram M.A., Kaprio J., Kemp J.P., Khaw K.T., Klopp N., Konte B., Kutalik Z., Lahti J., Li X., Loos RJF, Luciano M., Magnusson S.H., Mangino M., Marques-Vidal P., Martin N.G., McArdle W.L., McCarthy M.I., Medina-Gomez C., Melbye M., Melville S.A., Metspalu A., Milani L., Mooser V., Nelis M., Nyholt D.R., O'Connell K.S., Ophoff R.A., Palmer C., Palotie A., Palviainen T., Pare G., Paternoster L., Peltonen L., Penninx BWJH, Polasek O., Pramstaller P.P., Prokopenko I., Raikkonen K., Ripatti S., Rivadeneira F., Rudan I., Rujescu D., Smit J.H., Smith G.D., Smoller J.W., Soranzo N., Spector T.D., Pourcain B.S., Starr J.M., Stefánsson H., Steinberg S., Teder-Laving M., Thorleifsson G., Stefánsson K., Timpson N.J., Uitterlinden A.G., van Duijn C.M., van Rooij FJA, Vink J.M., Vollenweider P., Vuoksimaa E., Waeber G., Wareham N.J., Warrington N., Waterworth D., Werge T., Wichmann H.E., Widen E., Willemsen G., Wright A.F., Wright M.J., Xu M., Zhao J.H., Kraft P., Hinds D.A., Lindgren C.M., Mägi R., Neale B.M., Evans D.M., Medland S.E.
ISSN
2397-3374 (Electronic)
ISSN-L
2397-3374
Publication state
Published
Issued date
01/2021
Peer-reviewed
Oui
Volume
5
Number
1
Pages
59-70
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10 <sup>-8</sup> ) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (r <sub>G</sub> = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.
Keywords
Adult, Aged, Female, Functional Laterality/genetics, Gene Frequency/genetics, Genetic Loci/genetics, Genetic Variation/genetics, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Single Nucleotide/genetics, Quantitative Trait, Heritable, Sex Factors
Pubmed
Web of science
Create date
05/10/2020 13:00
Last modification date
17/03/2021 6:26
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