Host Molecule Incorporation into HIV Virions, Potential Influences in HIV Pathogenesis.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_E603E7404562
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Host Molecule Incorporation into HIV Virions, Potential Influences in HIV Pathogenesis.
Périodique
Viruses
ISSN
1999-4915 (Electronic)
ISSN-L
1999-4915
Statut éditorial
Publié
Date de publication
14/11/2022
Peer-reviewed
Oui
Volume
14
Numéro
11
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
During the last phase of HIV viral production, nascent HIV virions acquire a fraction of the cellular lipid membrane to create the external lipid envelope, a process by which cellular proteins present on the surface of the infected cell can be incorporated along with Env trimers. Interestingly, several studies indicated that these incorporated host molecules could conserve their biological activity and consequently contribute to HIV pathogenesis either by enhancing the infectivity of HIV virions, their tissue tropism or by affecting immune cell functions. The following review will describe the main approaches used to characterize membrane bound host molecule incorporation into HIV virions, the proposed mechanisms involved, and the role of a non-exhaustive list of incorporated molecules.
Mots-clé
Humans, HIV-1/physiology, Virion/metabolism, Cell Membrane, HIV Infections/metabolism, Lipids, HIV, pathogenesis, protein incorporation, replication cycle
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/02/2023 12:29
Dernière modification de la notice
25/11/2023 8:22