Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group

Détails

ID Serval
serval:BIB_E584D7742EEA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group
Périodique
Contact Dermatitis
Auteur⸱e⸱s
Perrenoud  D., Bircher  A., Hunziker  T., Suter  H., Bruckner-Tuderman  L., Stager  J., Thurlimann  W., Schmid  P., Suard  A., Hunziker  N.
ISSN
0105-1873
Statut éditorial
Publié
Date de publication
05/1994
Peer-reviewed
Oui
Volume
30
Numéro
5
Pages
276-9
Notes
Journal Article
Multicenter Study
Review --- Old month value: May
Résumé
From February 1989 to January 1990, the Swiss Contact Dermatitis Research Group conducted a 1-year study to examine the frequency of sensitization to a series of 13 common preservatives. A group of 2295 consecutive outpatients with suspected allergic contact dermatitis (age range 7-90 years, with a mean age of 42; 911 males, 1384 females) was tested. The %s of positive reactions to the preservatives studied are as follows, in descending order: formaldehyde 5.7%, benzalkonium chloride 5.5%, Kathon CG 5.5%, thimerosal 4.2%, chlorhexidine digluconate 2.0%, DMDM hydantoin 1.7%, paraben mix 1.7%, chloroacetamide 1.5%, Bronopol 1.2%, imidazolidinyl urea 1.0%, quaternium 15 1.0%, triclosan 0.8%, 2,4-dichlorobenzyl alcohol 0.4%. These relatively high values suggest a heavy exposure of the Swiss population to topical preservatives. Compared to previous studies, the sensitization rate to Kathon CG has stabilized in Switzerland over the last 2 years. Sensitization to formaldehyde portrayed impressive geographical variation, with sensitization rates up to 9% in western and only 3% in eastern Switzerland. The low sensitization rate to parabens argues for their inclusion in a medicament or preservative series, rather than in the standard series.
Mots-clé
Administration, Cutaneous Adolescent Adult Aged Aged, 80 and over Allergens/*adverse effects Child Dermatitis, Allergic Contact/diagnosis/epidemiology/*etiology Female Humans Incidence Male Middle Aged Preservatives, Pharmaceutical/*adverse effects Skin Tests Switzerland/epidemiology
Pubmed
Web of science
Création de la notice
15/02/2008 14:07
Dernière modification de la notice
20/08/2019 17:08
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