Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group

Details

Serval ID
serval:BIB_E584D7742EEA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group
Journal
Contact Dermatitis
Author(s)
Perrenoud  D., Bircher  A., Hunziker  T., Suter  H., Bruckner-Tuderman  L., Stager  J., Thurlimann  W., Schmid  P., Suard  A., Hunziker  N.
ISSN
0105-1873
Publication state
Published
Issued date
05/1994
Peer-reviewed
Oui
Volume
30
Number
5
Pages
276-9
Notes
Journal Article
Multicenter Study
Review --- Old month value: May
Abstract
From February 1989 to January 1990, the Swiss Contact Dermatitis Research Group conducted a 1-year study to examine the frequency of sensitization to a series of 13 common preservatives. A group of 2295 consecutive outpatients with suspected allergic contact dermatitis (age range 7-90 years, with a mean age of 42; 911 males, 1384 females) was tested. The %s of positive reactions to the preservatives studied are as follows, in descending order: formaldehyde 5.7%, benzalkonium chloride 5.5%, Kathon CG 5.5%, thimerosal 4.2%, chlorhexidine digluconate 2.0%, DMDM hydantoin 1.7%, paraben mix 1.7%, chloroacetamide 1.5%, Bronopol 1.2%, imidazolidinyl urea 1.0%, quaternium 15 1.0%, triclosan 0.8%, 2,4-dichlorobenzyl alcohol 0.4%. These relatively high values suggest a heavy exposure of the Swiss population to topical preservatives. Compared to previous studies, the sensitization rate to Kathon CG has stabilized in Switzerland over the last 2 years. Sensitization to formaldehyde portrayed impressive geographical variation, with sensitization rates up to 9% in western and only 3% in eastern Switzerland. The low sensitization rate to parabens argues for their inclusion in a medicament or preservative series, rather than in the standard series.
Keywords
Administration, Cutaneous Adolescent Adult Aged Aged, 80 and over Allergens/*adverse effects Child Dermatitis, Allergic Contact/diagnosis/epidemiology/*etiology Female Humans Incidence Male Middle Aged Preservatives, Pharmaceutical/*adverse effects Skin Tests Switzerland/epidemiology
Pubmed
Web of science
Create date
15/02/2008 13:07
Last modification date
20/08/2019 16:08
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