Lactitol: gastrointestinal absorption and effect on blood lactate in healthy volunteers and patients with cirrhosis.

Détails

ID Serval
serval:BIB_E51BCA895665
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Lactitol: gastrointestinal absorption and effect on blood lactate in healthy volunteers and patients with cirrhosis.
Périodique
European Journal of Clinical Pharmacology
Auteur⸱e⸱s
Metzger J., Chollet C., Wermeille M., Biollaz J., Llull J.B., Lauterburg B.H.
ISSN
0031-6970 (Print)
ISSN-L
0031-6970
Statut éditorial
Publié
Date de publication
1988
Peer-reviewed
Oui
Volume
35
Numéro
1
Pages
97-99
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The gastrointestinal absorption of lactitol has been studied in 6 healthy volunteers and 8 patients with cirrhosis. Following administration of lactitol 0.5 g/kg, no lactitol was found in serum. The urinary excretion of lactitol over 24 h ranged from 0.1 to 1.4% of the administered dose (0.46% in cirrhotics and 0.35% in healthy volunteers). Blood D- and L-lactate and plasma glucose did not increase following lactitol. The data indicate that lactitol was poorly absorbed from the gastrointestinal tract in healthy volunteers and patients with cirrhosis, and that the disaccharide did not disturb glucose or lactate homeostasis.
Mots-clé
Adult, Female, Humans, Hydrogen-Ion Concentration, Intestinal Absorption, Lactates/blood, Liver Cirrhosis/blood, Liver Cirrhosis, Alcoholic/blood, Male, Stereoisomerism, Sugar Alcohols/pharmacokinetics
Pubmed
Web of science
Création de la notice
25/01/2008 11:41
Dernière modification de la notice
20/08/2019 17:08
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