Lactitol: gastrointestinal absorption and effect on blood lactate in healthy volunteers and patients with cirrhosis.

Details

Serval ID
serval:BIB_E51BCA895665
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lactitol: gastrointestinal absorption and effect on blood lactate in healthy volunteers and patients with cirrhosis.
Journal
European Journal of Clinical Pharmacology
Author(s)
Metzger J., Chollet C., Wermeille M., Biollaz J., Llull J.B., Lauterburg B.H.
ISSN
0031-6970 (Print)
ISSN-L
0031-6970
Publication state
Published
Issued date
1988
Peer-reviewed
Oui
Volume
35
Number
1
Pages
97-99
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The gastrointestinal absorption of lactitol has been studied in 6 healthy volunteers and 8 patients with cirrhosis. Following administration of lactitol 0.5 g/kg, no lactitol was found in serum. The urinary excretion of lactitol over 24 h ranged from 0.1 to 1.4% of the administered dose (0.46% in cirrhotics and 0.35% in healthy volunteers). Blood D- and L-lactate and plasma glucose did not increase following lactitol. The data indicate that lactitol was poorly absorbed from the gastrointestinal tract in healthy volunteers and patients with cirrhosis, and that the disaccharide did not disturb glucose or lactate homeostasis.
Keywords
Adult, Female, Humans, Hydrogen-Ion Concentration, Intestinal Absorption, Lactates/blood, Liver Cirrhosis/blood, Liver Cirrhosis, Alcoholic/blood, Male, Stereoisomerism, Sugar Alcohols/pharmacokinetics
Pubmed
Web of science
Create date
25/01/2008 10:41
Last modification date
20/08/2019 16:08
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