Large-Scale 3-5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_E4C723D9F33C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Large-Scale 3-5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy.
Périodique
eNeuro
Auteur(s)
Sheybani L., van Mierlo P., Birot G., Michel C.M., Quairiaux C.
ISSN
2373-2822 (Electronic)
ISSN-L
2373-2822
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
6
Numéro
1
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Large-scale slow oscillations allow the integration of neuronal activity across brain regions during sensory or cognitive processing. However, evidence that this form of coding also holds for pathological networks, such as for distributed networks in epileptic disorders, does not yet exist. Here, we show in a mouse model of unilateral hippocampal epilepsy that epileptic fast ripples generated in the neocortex distant from the primary focus occur during transient trains of interictal epileptic discharges. During these epileptic paroxysms, local phase-locking of neuronal firing and a phase-amplitude coupling of the epileptic discharges over a slow oscillation at 3-5 Hz are detected. Furthermore, the buildup of the slow oscillation begins in the bihippocampal network that includes the focus, which synchronizes and drives the activity across the large-scale epileptic network into the frontal cortex. This study provides the first functional description of the emergence of neocortical fast ripples in hippocampal epilepsy and shows that cross-frequency coupling might be a fundamental mechanism underlying the spreading of epileptic activity.
Mots-clé
Action Potentials, Animals, Brain Waves/physiology, Disease Models, Animal, Epilepsy, Temporal Lobe/physiopathology, Male, Mice, Inbred C57BL, Neocortex/physiopathology, Neurons/physiology, cross-frequency coupling, epilepsy, epileptic network, fast-ripples, oscillation
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/03/2019 19:12
Dernière modification de la notice
21/08/2019 6:10
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