Large-Scale 3-5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy.

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License: CC BY 4.0
Serval ID
serval:BIB_E4C723D9F33C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Large-Scale 3-5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy.
Journal
eNeuro
Author(s)
Sheybani L., van Mierlo P., Birot G., Michel C.M., Quairiaux C.
ISSN
2373-2822 (Electronic)
ISSN-L
2373-2822
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
6
Number
1
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Large-scale slow oscillations allow the integration of neuronal activity across brain regions during sensory or cognitive processing. However, evidence that this form of coding also holds for pathological networks, such as for distributed networks in epileptic disorders, does not yet exist. Here, we show in a mouse model of unilateral hippocampal epilepsy that epileptic fast ripples generated in the neocortex distant from the primary focus occur during transient trains of interictal epileptic discharges. During these epileptic paroxysms, local phase-locking of neuronal firing and a phase-amplitude coupling of the epileptic discharges over a slow oscillation at 3-5 Hz are detected. Furthermore, the buildup of the slow oscillation begins in the bihippocampal network that includes the focus, which synchronizes and drives the activity across the large-scale epileptic network into the frontal cortex. This study provides the first functional description of the emergence of neocortical fast ripples in hippocampal epilepsy and shows that cross-frequency coupling might be a fundamental mechanism underlying the spreading of epileptic activity.
Keywords
Action Potentials, Animals, Brain Waves/physiology, Disease Models, Animal, Epilepsy, Temporal Lobe/physiopathology, Male, Mice, Inbred C57BL, Neocortex/physiopathology, Neurons/physiology, cross-frequency coupling, epilepsy, epileptic network, fast-ripples, oscillation
Pubmed
Web of science
Open Access
Yes
Create date
25/03/2019 19:12
Last modification date
21/08/2019 6:10
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