Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection.

Détails

ID Serval
serval:BIB_E4B458967B9E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection.
Périodique
Cytokine
Auteur⸱e⸱s
Delaloye J., De Bruin I.J., Darling K.E., Reymond M.K., Sweep F.C., Roger T., Calandra T., Cavassini M.
ISSN
1096-0023 (Electronic)
ISSN-L
1043-4666
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
60
Numéro
2
Pages
338-340
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Considering macrophage migratory inhibitory factor (MIF) as a critical pro-inflammatory cytokine of the immune system, we evaluated plasma MIF levels in 89 HIV-infected adults. Plasma MIF levels were higher in HIV-infected than in HIV-negative individuals. Highest MIF levels were observed during acute HIV infection (AHI) whilst patients on antiretroviral therapy (ART) had lower MIF levels, regardless of ART efficacy. Our results suggest that MIF is an integral component of the cytokine storm characteristic of AHI.
Pubmed
Web of science
Création de la notice
20/12/2012 18:52
Dernière modification de la notice
09/04/2020 5:20
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