Pathogenesis and Therapy of Primary Cutaneous T-Cell Lymphoma: Collegium Internationale Allergologicum (CIA) Update 2020.

Détails

ID Serval
serval:BIB_E41BEC470D91
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Pathogenesis and Therapy of Primary Cutaneous T-Cell Lymphoma: Collegium Internationale Allergologicum (CIA) Update 2020.
Périodique
International archives of allergy and immunology
Auteur(s)
Bobrowicz M., Fassnacht C., Ignatova D., Chang Y.T., Dimitriou F., Guenova E.
ISSN
1423-0097 (Electronic)
ISSN-L
1018-2438
Statut éditorial
Publié
Date de publication
2020
Peer-reviewed
Oui
Volume
181
Numéro
10
Pages
733-745
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous disease group of unknown etiology with a complex immunological background. As CTCL arises from T cells that have a vital role in the antitumor response, their therapy is largely aimed at reversing the immunological mechanisms leading to or manifesting during this malignancy. Early disease stages can be controlled with skin-directed therapy in most CTCL cases. Still, advanced CTCL has a dismal prognosis and warrants systemic therapy. Despite considerable progress in understanding the pathophysiology of the disease and the numerous systemic treatment options available, long-term remission rates with conventional treatments alone are still low. Allogeneic hematopoietic stem cell transplantation is currently the only curative option for advanced CTCL, including mycosis fungoides and Sézary syndrome. The aims of this review is to summarize the recent findings on the immunology of this heterogeneous disease and to present the advances in its clinical management.
Mots-clé
Pathogenesis, Skin, T-cell lymphoma
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/07/2020 12:59
Dernière modification de la notice
07/07/2021 5:36
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