Pathogenesis and Therapy of Primary Cutaneous T-Cell Lymphoma: Collegium Internationale Allergologicum (CIA) Update 2020.

Details

Serval ID
serval:BIB_E41BEC470D91
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Pathogenesis and Therapy of Primary Cutaneous T-Cell Lymphoma: Collegium Internationale Allergologicum (CIA) Update 2020.
Journal
International archives of allergy and immunology
Author(s)
Bobrowicz M., Fassnacht C., Ignatova D., Chang Y.T., Dimitriou F., Guenova E.
ISSN
1423-0097 (Electronic)
ISSN-L
1018-2438
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
181
Number
10
Pages
733-745
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous disease group of unknown etiology with a complex immunological background. As CTCL arises from T cells that have a vital role in the antitumor response, their therapy is largely aimed at reversing the immunological mechanisms leading to or manifesting during this malignancy. Early disease stages can be controlled with skin-directed therapy in most CTCL cases. Still, advanced CTCL has a dismal prognosis and warrants systemic therapy. Despite considerable progress in understanding the pathophysiology of the disease and the numerous systemic treatment options available, long-term remission rates with conventional treatments alone are still low. Allogeneic hematopoietic stem cell transplantation is currently the only curative option for advanced CTCL, including mycosis fungoides and Sézary syndrome. The aims of this review is to summarize the recent findings on the immunology of this heterogeneous disease and to present the advances in its clinical management.
Keywords
Pathogenesis, Skin, T-cell lymphoma
Pubmed
Web of science
Open Access
Yes
Create date
24/07/2020 12:59
Last modification date
07/07/2021 5:36
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