Functional management of an antiviral cytotoxic T-cell response
Détails
ID Serval
serval:BIB_E269B4FE17F3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Functional management of an antiviral cytotoxic T-cell response
Périodique
Journal of Virology
ISSN
0022-538X (Print)
Statut éditorial
Publié
Date de publication
08/1997
Volume
71
Numéro
8
Pages
5764-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
Lymphocytic choriomeningitis virus (LCMV) is known to induce strong, polyclonal cytotoxic T-lymphocyte (CTL) responses. Using a set of variant peptides derived from the major CTL epitope of LCMV, we analyzed the functional fine specificity of the LCMV-specific CTL response. During the primary response, almost all the tested peptides were recognized. In contrast, the secondary response was purged of all minor cross-reactivities and very few peptides were significantly recognized. This study is the first demonstration of the functional maturation of a T-cell response and has important clinical and biological implications.
Mots-clé
Animals
Antibodies, Monoclonal/immunology
Lymphocytic choriomeningitis virus/*immunology
Mice
Mice, Inbred C57BL
Mutation
T-Lymphocytes, Cytotoxic/*physiology
Pubmed
Web of science
Création de la notice
28/01/2008 12:33
Dernière modification de la notice
20/08/2019 17:06