Functional management of an antiviral cytotoxic T-cell response

Details

Serval ID
serval:BIB_E269B4FE17F3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Functional management of an antiviral cytotoxic T-cell response
Journal
Journal of Virology
Author(s)
Bachmann  M. F., Speiser  D. E., Ohashi  P. S.
ISSN
0022-538X (Print)
Publication state
Published
Issued date
08/1997
Volume
71
Number
8
Pages
5764-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
Lymphocytic choriomeningitis virus (LCMV) is known to induce strong, polyclonal cytotoxic T-lymphocyte (CTL) responses. Using a set of variant peptides derived from the major CTL epitope of LCMV, we analyzed the functional fine specificity of the LCMV-specific CTL response. During the primary response, almost all the tested peptides were recognized. In contrast, the secondary response was purged of all minor cross-reactivities and very few peptides were significantly recognized. This study is the first demonstration of the functional maturation of a T-cell response and has important clinical and biological implications.
Keywords
Animals Antibodies, Monoclonal/immunology Lymphocytic choriomeningitis virus/*immunology Mice Mice, Inbred C57BL Mutation T-Lymphocytes, Cytotoxic/*physiology
Pubmed
Web of science
Create date
28/01/2008 11:33
Last modification date
20/08/2019 16:06
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