SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability.

Détails

ID Serval
serval:BIB_E24D37BB1394
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability.
Périodique
Biochimica et Biophysica Acta
Auteur(s)
Da Cruz S., Parone P.A., Gonzalo P., Bienvenut W.V., Tondera D., Jourdain A., Quadroni M., Martinou J.C.
ISSN
0167-4889
Statut éditorial
Publié
Date de publication
02/2008
Peer-reviewed
Oui
Volume
1783
Numéro
5
Pages
904-911
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Stomatin is a member of a large family of proteins including prohibitins, HflK/C, flotillins, mechanoreceptors and plant defense proteins, that are thought to play a role in protein turnover. Using different proteomic approaches, we and others have identified SLP-2, a member of the stomatin gene family, as a component of the mitochondria. In this study, we show that SLP-2 is strongly associated with the mitochondrial inner membrane and that it interacts with prohibitins. Depleting HeLa cells of SLP-2 lead to increased proteolysis of prohibitins and of subunits of the respiratory chain complexes I and IV. Further supporting the role of SLP-2 in regulating the stability of specific mitochondrial proteins, we found that SLP-2 is up-regulated under conditions of mitochondrial stress leading to increased protein turnover. These data indicate that SLP-2 plays a role in regulating the stability of mitochondrial proteins including prohibitins and subunits of respiratory chain complexes.
Mots-clé
Animals, Blood Proteins/metabolism, Cells, Cultured, Electron Transport Complex I/metabolism, Electron Transport Complex IV/metabolism, HeLa Cells, Humans, Immunoprecipitation, Membrane Proteins/metabolism, Mitochondria/metabolism, Mitochondrial Membranes/metabolism, Mitochondrial Proteins/metabolism, Repressor Proteins/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/03/2008 9:08
Dernière modification de la notice
20/08/2019 16:06
Données d'usage