Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway.

Détails

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Etat: Public
Version: de l'auteur⸱e
Licence: CC BY 4.0
ID Serval
serval:BIB_E14A050AB1CD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway.
Périodique
Current pharmaceutical design
Auteur⸱e⸱s
Paunkov A., Chartoumpekis D.V., Ziros P.G., Chondrogianni N., Kensler T.W., Sykiotis G.P.
ISSN
1873-4286 (Electronic)
ISSN-L
1381-6128
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
25
Numéro
16
Pages
1828-1846
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Natural compounds with potential antioxidant properties have been used in the form of food supplements or extracts with the intent to prevent or treat various diseases. Many of these compounds can activate the cytoprotective Nrf2 pathway. Besides, some of them are known to impact the thyroid gland, often with potential side-effects, but in other instances, with potential utility in the treatment of thyroid disorders.
In view of recent data regarding the multiple roles of Nrf2 in the thyroid, this review summarizes the current bibliography on natural compounds that can have an effect on thyroid gland physiology and pathophysiology, and it discusses the potential implication of the Nrf2 system in the respective mechanisms.
Literature searches for articles from 1950 to 2018 were performed in PubMed and Google Scholar using relevant keywords about phytochemicals, Nrf2 and thyroid. Natural substances were categorized into phenolic compounds, sulfur-containing compounds, quinones, terpenoids, or under the general category of plant extracts. For individual compounds in each category, respective data were summarized, as derived from in vitro (cell lines), preclinical (animal models) and clinical studies. The main emerging themes were as follows: phenolic compounds often showed potential to affect the production of thyroid hormones; sulfur-containing compounds impacted the pathogenesis of goiter and the proliferation of thyroid cancer cells; while quinones and terpenoids modified Nrf2 signaling in thyroid cell lines.
Natural compounds that modify the activity of the Nrf2 pathway should be evaluated carefully, not only for their potential to be used as therapeutic agents for thyroid disorders, but also for their thyroidal safety when used for the prevention and treatment of non-thyroidal diseases.
Mots-clé
Animals, Antioxidants/pharmacology, Cell Line, Humans, Kelch-Like ECH-Associated Protein 1/physiology, NF-E2-Related Factor 2/physiology, Phytochemicals/pharmacology, Signal Transduction, Thyroid Gland/drug effects, Thyroid Gland/physiology, Nrf2, Personalized nutrition, flavonoid, goiter, hyperthyroidism, hypothyroidism, phytochemical, thyroid.
Pubmed
Web of science
Open Access
Oui
Financement(s)
Fonds national suisse / Programmes / 31003A_153062
Fonds national suisse / Programmes / 31003A_182105
Fondation Leenaards / 2016 Fellowship for Academic Promotion in Clinical Medicine
Fonds national suisse / Programmes / IZCOZ0_177070
SEFRI / 174626 -C15.0045
Création de la notice
18/07/2019 16:12
Dernière modification de la notice
03/10/2023 21:43
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