Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway.

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_E14A050AB1CD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway.
Journal
Current pharmaceutical design
Author(s)
Paunkov A., Chartoumpekis D.V., Ziros P.G., Chondrogianni N., Kensler T.W., Sykiotis G.P.
ISSN
1873-4286 (Electronic)
ISSN-L
1381-6128
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
25
Number
16
Pages
1828-1846
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Natural compounds with potential antioxidant properties have been used in the form of food supplements or extracts with the intent to prevent or treat various diseases. Many of these compounds can activate the cytoprotective Nrf2 pathway. Besides, some of them are known to impact the thyroid gland, often with potential side-effects, but in other instances, with potential utility in the treatment of thyroid disorders.
In view of recent data regarding the multiple roles of Nrf2 in the thyroid, this review summarizes the current bibliography on natural compounds that can have an effect on thyroid gland physiology and pathophysiology, and it discusses the potential implication of the Nrf2 system in the respective mechanisms.
Literature searches for articles from 1950 to 2018 were performed in PubMed and Google Scholar using relevant keywords about phytochemicals, Nrf2 and thyroid. Natural substances were categorized into phenolic compounds, sulfur-containing compounds, quinones, terpenoids, or under the general category of plant extracts. For individual compounds in each category, respective data were summarized, as derived from in vitro (cell lines), preclinical (animal models) and clinical studies. The main emerging themes were as follows: phenolic compounds often showed potential to affect the production of thyroid hormones; sulfur-containing compounds impacted the pathogenesis of goiter and the proliferation of thyroid cancer cells; while quinones and terpenoids modified Nrf2 signaling in thyroid cell lines.
Natural compounds that modify the activity of the Nrf2 pathway should be evaluated carefully, not only for their potential to be used as therapeutic agents for thyroid disorders, but also for their thyroidal safety when used for the prevention and treatment of non-thyroidal diseases.
Keywords
Animals, Antioxidants/pharmacology, Cell Line, Humans, Kelch-Like ECH-Associated Protein 1/physiology, NF-E2-Related Factor 2/physiology, Phytochemicals/pharmacology, Signal Transduction, Thyroid Gland/drug effects, Thyroid Gland/physiology, Nrf2, Personalized nutrition, flavonoid, goiter, hyperthyroidism, hypothyroidism, phytochemical, thyroid.
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Programmes / 31003A_153062
Swiss National Science Foundation / Programmes / 31003A_182105
Fondation Leenaards / 2016 Fellowship for Academic Promotion in Clinical Medicine
Swiss National Science Foundation / Programmes / IZCOZ0_177070
SERI (SEFRI) / 174626 -C15.0045
Create date
18/07/2019 16:12
Last modification date
21/11/2022 8:30
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