Effet de substances anti-inflammatoires sur le chimiotactisme des poly-nucleaires humains etudie in vitro. [Effect of anti-inflammatory agents on chemotaxis of human neutrophils studied in vitro]

Détails

ID Serval
serval:BIB_DED686EEC477
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effet de substances anti-inflammatoires sur le chimiotactisme des poly-nucleaires humains etudie in vitro. [Effect of anti-inflammatory agents on chemotaxis of human neutrophils studied in vitro]
Périodique
Schweizerische Medizinische Wochenschrift
Auteur(s)
Pecoud  A., Leimgruber  A., Frei  P. C.
ISSN
0036-7672 (Print)
Statut éditorial
Publié
Date de publication
12/1978
Volume
108
Numéro
49
Pages
1969-70
Notes
English Abstract
Journal Article --- Old month value: Dec 9
Résumé
Using a modified Boyden chamber the effect of three antiinflammatory drugs on the chemotaxis of human neutrophils has been tested in vitro. Gold salt produced a reduction of both neutrophil migration and the ability of plasma to attract this cell. Betamethasone decreased chemotaxis by an action on the cell itself but not on the plasma. Aspirin had no effect on this function. These data suggest that antiinflammatory drugs act through different mechanisms and that the reduction of neutrophil chemotaxis may contribute to the antiinflammatory action of gold salts.
Mots-clé
1-Propanol/pharmacology Anti-Inflammatory Agents/*pharmacology Aspirin/analogs & derivatives/pharmacology Betamethasone/pharmacology Chemotaxis, Leukocyte/*drug effects Gold/pharmacology Humans Lysine/analogs & derivatives/pharmacology Neutrophils/drug effects Propanols
Pubmed
Web of science
Création de la notice
28/01/2008 12:59
Dernière modification de la notice
20/08/2019 17:03
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