Effet de substances anti-inflammatoires sur le chimiotactisme des poly-nucleaires humains etudie in vitro. [Effect of anti-inflammatory agents on chemotaxis of human neutrophils studied in vitro]

Details

Serval ID
serval:BIB_DED686EEC477
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effet de substances anti-inflammatoires sur le chimiotactisme des poly-nucleaires humains etudie in vitro. [Effect of anti-inflammatory agents on chemotaxis of human neutrophils studied in vitro]
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Pecoud  A., Leimgruber  A., Frei  P. C.
ISSN
0036-7672 (Print)
Publication state
Published
Issued date
12/1978
Volume
108
Number
49
Pages
1969-70
Notes
English Abstract
Journal Article --- Old month value: Dec 9
Abstract
Using a modified Boyden chamber the effect of three antiinflammatory drugs on the chemotaxis of human neutrophils has been tested in vitro. Gold salt produced a reduction of both neutrophil migration and the ability of plasma to attract this cell. Betamethasone decreased chemotaxis by an action on the cell itself but not on the plasma. Aspirin had no effect on this function. These data suggest that antiinflammatory drugs act through different mechanisms and that the reduction of neutrophil chemotaxis may contribute to the antiinflammatory action of gold salts.
Keywords
1-Propanol/pharmacology Anti-Inflammatory Agents/*pharmacology Aspirin/analogs & derivatives/pharmacology Betamethasone/pharmacology Chemotaxis, Leukocyte/*drug effects Gold/pharmacology Humans Lysine/analogs & derivatives/pharmacology Neutrophils/drug effects Propanols
Pubmed
Web of science
Create date
28/01/2008 11:59
Last modification date
20/08/2019 16:03
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