Bone Muscle Crosstalk in Spinal Cord Injuries: Pathophysiology and Implications for Patients' Quality of Life.

Détails

Ressource 1Demande d'une copie Sous embargo indéterminé.
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
ID Serval
serval:BIB_DE7C56F9BAC1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Bone Muscle Crosstalk in Spinal Cord Injuries: Pathophysiology and Implications for Patients' Quality of Life.
Périodique
Current osteoporosis reports
Auteur(s)
Invernizzi M., de Sire A., Carda S., Venetis K., Renò F., Cisari C., Fusco N.
ISSN
1544-2241 (Electronic)
ISSN-L
1544-1873
Statut éditorial
Publié
Date de publication
08/2020
Peer-reviewed
Oui
Volume
18
Numéro
4
Pages
422-431
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The goal of this review is to provide a comprehensive overview of (i) bone and muscle tissue modifications pathophysiology in spinal cord injury (SCI), (ii) experimental data on the physiopathological mechanisms underpinning these modifications and their similarities with the aging process, and (iii) potential clinical implications in the management of the disabling sequelae of SCI.
Several studies attempted to describe the biology underpinning the links between bone and muscle tissues in the setting of highly disabling conditions, such as osteoporosis, sarcopenia, and neurodegenerative disorders, although these bidirectional connections remain still unclear. SCI could be considered an in vivo paradigmatic model of the bone muscle interactions in unloading conditions that might be expanded in the field of neurodegenerative disorders or cancer studies. Future studies should take into consideration the newer insights into bone muscle crosstalk in order to develop multitargeted and therapeutic interventions.
Mots-clé
Bone, Bone loss, Muscle, Osteoporosis, Rehabilitation, Sarcopenia, Spinal cord injury
Pubmed
Web of science
Création de la notice
25/06/2020 17:35
Dernière modification de la notice
23/10/2020 6:23
Données d'usage