Bone Muscle Crosstalk in Spinal Cord Injuries: Pathophysiology and Implications for Patients' Quality of Life.

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State: Public
Version: author
License: Not specified
Serval ID
serval:BIB_DE7C56F9BAC1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Bone Muscle Crosstalk in Spinal Cord Injuries: Pathophysiology and Implications for Patients' Quality of Life.
Journal
Current osteoporosis reports
Author(s)
Invernizzi M., de Sire A., Carda S., Venetis K., Renò F., Cisari C., Fusco N.
ISSN
1544-2241 (Electronic)
ISSN-L
1544-1873
Publication state
Published
Issued date
08/2020
Peer-reviewed
Oui
Volume
18
Number
4
Pages
422-431
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The goal of this review is to provide a comprehensive overview of (i) bone and muscle tissue modifications pathophysiology in spinal cord injury (SCI), (ii) experimental data on the physiopathological mechanisms underpinning these modifications and their similarities with the aging process, and (iii) potential clinical implications in the management of the disabling sequelae of SCI.
Several studies attempted to describe the biology underpinning the links between bone and muscle tissues in the setting of highly disabling conditions, such as osteoporosis, sarcopenia, and neurodegenerative disorders, although these bidirectional connections remain still unclear. SCI could be considered an in vivo paradigmatic model of the bone muscle interactions in unloading conditions that might be expanded in the field of neurodegenerative disorders or cancer studies. Future studies should take into consideration the newer insights into bone muscle crosstalk in order to develop multitargeted and therapeutic interventions.
Keywords
Bone, Bone loss, Muscle, Osteoporosis, Rehabilitation, Sarcopenia, Spinal cord injury
Pubmed
Web of science
Create date
25/06/2020 17:35
Last modification date
23/10/2020 6:23
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