Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_DDF7738832AC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia.
Périodique
Schizophrenia Bulletin
Auteur(s)
Do K.Q., Cuenod M., Hensch T.K.
ISSN
1745-1701 (Electronic)
ISSN-L
0586-7614
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
41
Numéro
4
Pages
835-846
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Schizophrenia is a neurodevelopmental disorder reflecting a convergence of genetic risk and early life stress. The slow progression to first psychotic episode represents both a window of vulnerability as well as opportunity for therapeutic intervention. Here, we consider recent neurobiological insight into the cellular and molecular components of developmental critical periods and their vulnerability to redox dysregulation. In particular, the consistent loss of parvalbumin-positive interneuron (PVI) function and their surrounding perineuronal nets (PNNs) as well as myelination in patient brains is consistent with a delayed or extended period of circuit instability. This linkage to critical period triggers (PVI) and brakes (PNN, myelin) implicates mistimed trajectories of brain development in mental illness. Strategically introduced antioxidant treatment or later reinforcement of molecular brakes may then offer a novel prophylactic psychiatry.
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/06/2015 13:35
Dernière modification de la notice
20/08/2019 17:02
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