Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia.

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State: Public
Version: author
Serval ID
serval:BIB_DDF7738832AC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia.
Journal
Schizophrenia Bulletin
Author(s)
Do K.Q., Cuenod M., Hensch T.K.
ISSN
1745-1701 (Electronic)
ISSN-L
0586-7614
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
41
Number
4
Pages
835-846
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Schizophrenia is a neurodevelopmental disorder reflecting a convergence of genetic risk and early life stress. The slow progression to first psychotic episode represents both a window of vulnerability as well as opportunity for therapeutic intervention. Here, we consider recent neurobiological insight into the cellular and molecular components of developmental critical periods and their vulnerability to redox dysregulation. In particular, the consistent loss of parvalbumin-positive interneuron (PVI) function and their surrounding perineuronal nets (PNNs) as well as myelination in patient brains is consistent with a delayed or extended period of circuit instability. This linkage to critical period triggers (PVI) and brakes (PNN, myelin) implicates mistimed trajectories of brain development in mental illness. Strategically introduced antioxidant treatment or later reinforcement of molecular brakes may then offer a novel prophylactic psychiatry.
Pubmed
Web of science
Open Access
Yes
Create date
16/06/2015 13:35
Last modification date
20/08/2019 17:02
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