Gene therapy for primary immune deficiencies

Détails

ID Serval
serval:BIB_DD848FF37D21
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Gene therapy for primary immune deficiencies
Périodique
Curr Opin Allergy Clin Immunol
Auteur(s)
Otsu M., Wada T., Candotti F.
ISSN
1528-4050 (Print)
ISSN-L
1473-6322
Statut éditorial
Publié
Date de publication
12/2001
Volume
1
Numéro
6
Pages
497-501
Langue
anglais
Notes
Otsu, M
Wada, T
Candotti, F
eng
Review
Curr Opin Allergy Clin Immunol. 2001 Dec;1(6):497-501.
Résumé
Primary immunodeficiency diseases have been important targets of corrective gene transfer approaches since the very early days of gene therapy. The potential for selective survival advantage of gene-corrected cells over populations carrying the mutated, causative gene translates into the possibility of obtaining clinical meaningful results in patients with primary immunodeficiency diseases even if levels of gene transfer are low. This critical prospect has fueled the interest of researchers since the mid-1980s and has recently determined the success of a clinical trial of gene therapy for X-linked severe combined immunodeficiency.
Mots-clé
Animals, Genetic Therapy/*methods, Humans, Immunologic Deficiency Syndromes/*therapy, Leukocyte-Adhesion Deficiency Syndrome/therapy, Mice, Severe Combined Immunodeficiency/therapy, X Chromosome
Pubmed
Création de la notice
01/11/2017 10:29
Dernière modification de la notice
20/08/2019 16:02
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