Gene therapy for primary immune deficiencies

Details

Serval ID
serval:BIB_DD848FF37D21
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Gene therapy for primary immune deficiencies
Journal
Curr Opin Allergy Clin Immunol
Author(s)
Otsu M., Wada T., Candotti F.
ISSN
1528-4050 (Print)
ISSN-L
1473-6322
Publication state
Published
Issued date
12/2001
Volume
1
Number
6
Pages
497-501
Language
english
Notes
Otsu, M
Wada, T
Candotti, F
eng
Review
Curr Opin Allergy Clin Immunol. 2001 Dec;1(6):497-501.
Abstract
Primary immunodeficiency diseases have been important targets of corrective gene transfer approaches since the very early days of gene therapy. The potential for selective survival advantage of gene-corrected cells over populations carrying the mutated, causative gene translates into the possibility of obtaining clinical meaningful results in patients with primary immunodeficiency diseases even if levels of gene transfer are low. This critical prospect has fueled the interest of researchers since the mid-1980s and has recently determined the success of a clinical trial of gene therapy for X-linked severe combined immunodeficiency.
Keywords
Animals, Genetic Therapy/*methods, Humans, Immunologic Deficiency Syndromes/*therapy, Leukocyte-Adhesion Deficiency Syndrome/therapy, Mice, Severe Combined Immunodeficiency/therapy, X Chromosome
Pubmed
Create date
01/11/2017 10:29
Last modification date
20/08/2019 16:02
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