Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice.
Détails
ID Serval
serval:BIB_DC637C4300C5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice.
Périodique
American Journal of Pathology
ISSN
0002-9440 (Print)
ISSN-L
0002-9440
Statut éditorial
Publié
Date de publication
1981
Volume
102
Numéro
3
Pages
396-402
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Suckling Swiss mice were injected daily for 8 days with either electrophoretically pure (EP) mouse interferon (s.a. 4.7 x 10(8) units/mg protein), major impurities obtained in the course of purification, or partially purified mouse interferon (s.a. 1.3 x 10(7) units/mg protein). Only EP or partially purified interferon inhibited growth, induced liver and kidney lesions, and killed mice. The authors conclude that interferon itself is responsible for these effects.
Mots-clé
Animal Population Groups/growth & development, Animals, Animals, Suckling/growth & development, Electrophoresis, Glomerulonephritis/etiology, Histocytochemistry, Interferons/isolation & purification, Interferons/toxicity, Kidney/drug effects, Kidney Diseases/etiology, Kidney Diseases/pathology, Liver/drug effects, Liver Diseases/etiology, Liver Diseases/pathology, Mice, Time Factors
Pubmed
Création de la notice
28/01/2008 12:37
Dernière modification de la notice
20/08/2019 17:01
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