Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice.
Details
Serval ID
serval:BIB_DC637C4300C5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice.
Journal
American Journal of Pathology
ISSN
0002-9440 (Print)
ISSN-L
0002-9440
Publication state
Published
Issued date
1981
Volume
102
Number
3
Pages
396-402
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Suckling Swiss mice were injected daily for 8 days with either electrophoretically pure (EP) mouse interferon (s.a. 4.7 x 10(8) units/mg protein), major impurities obtained in the course of purification, or partially purified mouse interferon (s.a. 1.3 x 10(7) units/mg protein). Only EP or partially purified interferon inhibited growth, induced liver and kidney lesions, and killed mice. The authors conclude that interferon itself is responsible for these effects.
Keywords
Animal Population Groups/growth & development, Animals, Animals, Suckling/growth & development, Electrophoresis, Glomerulonephritis/etiology, Histocytochemistry, Interferons/isolation & purification, Interferons/toxicity, Kidney/drug effects, Kidney Diseases/etiology, Kidney Diseases/pathology, Liver/drug effects, Liver Diseases/etiology, Liver Diseases/pathology, Mice, Time Factors
Pubmed
Create date
28/01/2008 11:37
Last modification date
20/08/2019 16:01
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