Catecholaminergic traits of chick sympathetic neurons may be differentially regulated by a cGMP-dependent pathway

Détails

ID Serval
serval:BIB_DC1B6749C8CC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Catecholaminergic traits of chick sympathetic neurons may be differentially regulated by a cGMP-dependent pathway
Périodique
Brain Research. Developmental Brain Research
Auteur(s)
Zurn  A. D.
ISSN
0165-3806 (Print)
Statut éditorial
Publié
Date de publication
01/1991
Volume
58
Numéro
1
Pages
105-10
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 15
Résumé
The purine metabolites inosine and adenosine selectively increase the catecholamine, but not the acetylcholine production in cultured chick superior cervical ganglion neurons via an as yet unknown intracellular pathway. In order to elucidate some of the molecular events involved in this differential regulation of neurotransmitter production by purines, the SCG neurons were cultured in the presence of cyclic nucleotide analogs and activators of adenylate and guanylate cyclase. Neither 8-bromo-cyclic AMP (8-Br-cAMP), 8-bromo-cyclic GMP (8-Br-cGMP), or forskolin, an activator of adenylate cyclase, could mimic the effect of inosine, i.e. differentially increase catecholamine production. Sodium nitroprusside, an activator of guanylate cyclase, however, has a strong potentiating action on the effect of inosine. The noradrenergic properties of chick sympathetic neurons may thus be differentially modulated by a cGMP-dependent pathway.
Mots-clé
8-Bromo Cyclic Adenosine Monophosphate/pharmacology Adenine/metabolism Animals Carbon Radioisotopes/diagnostic use Catecholamines/*biosynthesis Chick Embryo Cyclic GMP/*physiology Forskolin/pharmacology Inosine/metabolism Neurons/drug effects/*metabolism Neurotransmitter Agents/biosynthesis Nitroprusside/pharmacology Purines/metabolism Sympathetic Nervous System/drug effects/*metabolism Tritium/diagnostic use
Pubmed
Création de la notice
28/01/2008 8:44
Dernière modification de la notice
20/08/2019 16:01
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