Catecholaminergic traits of chick sympathetic neurons may be differentially regulated by a cGMP-dependent pathway
Details
Serval ID
serval:BIB_DC1B6749C8CC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Catecholaminergic traits of chick sympathetic neurons may be differentially regulated by a cGMP-dependent pathway
Journal
Brain Research. Developmental Brain Research
ISSN
0165-3806 (Print)
Publication state
Published
Issued date
01/1991
Volume
58
Number
1
Pages
105-10
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 15
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 15
Abstract
The purine metabolites inosine and adenosine selectively increase the catecholamine, but not the acetylcholine production in cultured chick superior cervical ganglion neurons via an as yet unknown intracellular pathway. In order to elucidate some of the molecular events involved in this differential regulation of neurotransmitter production by purines, the SCG neurons were cultured in the presence of cyclic nucleotide analogs and activators of adenylate and guanylate cyclase. Neither 8-bromo-cyclic AMP (8-Br-cAMP), 8-bromo-cyclic GMP (8-Br-cGMP), or forskolin, an activator of adenylate cyclase, could mimic the effect of inosine, i.e. differentially increase catecholamine production. Sodium nitroprusside, an activator of guanylate cyclase, however, has a strong potentiating action on the effect of inosine. The noradrenergic properties of chick sympathetic neurons may thus be differentially modulated by a cGMP-dependent pathway.
Keywords
8-Bromo Cyclic Adenosine Monophosphate/pharmacology
Adenine/metabolism
Animals
Carbon Radioisotopes/diagnostic use
Catecholamines/*biosynthesis
Chick Embryo
Cyclic GMP/*physiology
Forskolin/pharmacology
Inosine/metabolism
Neurons/drug effects/*metabolism
Neurotransmitter Agents/biosynthesis
Nitroprusside/pharmacology
Purines/metabolism
Sympathetic Nervous System/drug effects/*metabolism
Tritium/diagnostic use
Pubmed
Create date
28/01/2008 8:44
Last modification date
20/08/2019 16:01